Research Perspectives for Neuroimaging of Schizophrenia Spectrum Disorders

  • Eleanor Scutt
  • Stefan Borgwardt
  • Paolo Fusar-PoliEmail author


Current evidence from neuroimaging studies investigating schizophrenia spectrum disorders (SSDs) has suggested alterations in grey and white matter [1–3], ventricular volume [4, 5], structural and functional connectivity [6, 7] and neurotransmitter levels [8]. Some of these findings have been consistent, for example, in the case of reduced cortical grey matter [1] and increased lateral ventricle volume [4]; however, others have been less clear with findings of both increased and decreased connectivity across several brain regions [6, 7]. Also of interest are regions that have consistently been associated with structural and neurochemical abnormalities, such as the striatum [8, 9] and the growing area of the role of the immune system in the pathology of SSDs [10].



Clinical high risk


Diffusion tensor imaging




Fractional anisotropy


First-episode psychosis


Functional magnetic resonance imaging


Magnetic resonance imaging


Positron emission tomography


Schizophrenia spectrum disorders


Support vector modelling


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Eleanor Scutt
    • 1
  • Stefan Borgwardt
    • 2
  • Paolo Fusar-Poli
    • 1
    Email author
  1. 1.Department of Psychosis StudiesInstitute of Psychiatry Psychology and Neuroscience (IoPPN), King’s College LondonLondonUK
  2. 2.Department of Psychiatry (UPK)University of BaselBaselSwitzerland

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