Pathophysiology of Overactive Bladder

  • Márcio Augusto Averbeck
  • Howard B. Goldman


Overactive bladder (OAB) syndrome is defined by the International Continence Society as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency urinary incontinence, in the absence of urinary tract infection or other obvious pathologies. Various theories have been proposed to elucidate the pathophysiology of OAB. However, since the cause of OAB is often multifactorial and complex, there is not a unique and widely accepted pathophysiological mechanism to explain this syndrome. This chapter aims to describe the various hypotheses, which may help in understanding the origin of OAB symptoms.


Overactive bladder Urgency Urgency urinary incontinence Urinary bladder Detrusor overactivity Pathophysiology Myogenic Neurogenic Afferent Urothelium Microbiome Environmental factors Neuromodulation 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Márcio Augusto Averbeck
    • 1
  • Howard B. Goldman
    • 2
  1. 1.Neuro-Urology Coordinator, Videourodynamics Unit, Department of UrologyMoinhos de Vento HospitalPorto AlegreBrazil
  2. 2.Glickman Urologic and Kidney InstituteCleveland ClinicClevelandUSA

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