Intervillous Thrombosis

  • Eric K. MorgenEmail author
  • Brendan Fitzgerald
  • Sarah Keating


Coagulation of blood within the intervillous space may result in a variety of pathologic lesions, most of which have a laminated appearance and are commonly referred to as thrombi, haematomas or thrombohaematomas. Specific lesions include intervillous thrombus, subchorionic intervillous thrombus, massive subchorionic thrombohaematoma, basal intervillous thrombus, rounded intraplacental haematoma and basal plate plaque. These lesions have multiple potential aetiologies relating to the classical causes of coagulation (stasis, endothelial injury, hypercoagulability), including haemorrhage from fetal capillaries, stasis or abnormal flow of maternal blood (e.g., in severe villous oedema, during labour or in the subchorionic zone), maternal hypercoagulability and maternal hypertensive disease. As such, their clinical implications also vary widely depending on the specific diagnosis. In this chapter, the aetiology, nosology, epidemiology, macroscopy, microscopy and clinical associations of the above lesions are discussed.


Placenta Pathology Thrombosis Intervillous thrombus Thrombus Subchorionic 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Eric K. Morgen
    • 1
    • 2
    Email author
  • Brendan Fitzgerald
    • 3
    • 4
  • Sarah Keating
    • 1
    • 2
  1. 1.Mount Sinai HospitalTorontoCanada
  2. 2.Department of Laboratory Medicine and Pathobiology, Faculty of MedicineUniversity of TorontoTorontoCanada
  3. 3.Department of PathologyCork University HospitalCorkIreland
  4. 4.Department of PathologyUniversity College CorkCorkIreland

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