Embryonic Remnants and Pathology

  • Margaret J. EvansEmail author


Embryonic remnants are often found as incidental findings on routine microscopy. They are derived from the vitelline (omphalomesenteric) duct (the embryonic structure which connects the midgut lumen within the yolk sac to the developing fetus) and the allantois (the primitive extraembryonic urinary bladder). In most cases they are asymptomatic, but the vitelline duct may be associated with intestinal atresia and Meckel’s diverticulum, whilst pyelonephritis and abscess formation may complicate a persistent urachus (allantoic duct). Both types of remnant may present as cystic lesions of the cord. This chapter describes the embryology of such lesions, outlines the diagnostic features of each and briefly describes associated disorders.


Umbilical cord Vitelline duct remnant Vitellointestinal duct Omphalomesenteric duct Allantoic duct Urachal duct Urachal remnant 


  1. 1.
    Benirschke K, Driscoll SG. The pathology of the human placenta. Berlin: Springer-Verlag; 1967. p. 56–90.Google Scholar
  2. 2.
    Moore KL. The developing human. Philadelphia: Saunders; 1982.Google Scholar
  3. 3.
    Jauniaux E, De Munter C, Vanesse M, Wilkin P, Hustin J. Embryonic remnants of the umbilical cord: morphological and clinical aspects. Hum Pathol. 1989;20:458–62.CrossRefGoogle Scholar
  4. 4.
    Baergen RN. Manual of Benirschke and Kaufmann’s pathology of the human placenta. New York: Springer; 2005. p. 249–52.Google Scholar
  5. 5.
    Kadian YS, Verma A, Rattan KN, Kajal P. Vitellointestinal duct anomalies in infancy. J Neonatal Surg. 2016;5:30.CrossRefGoogle Scholar
  6. 6.
    Copp HL, Wong I, Krishnan C, Malhotra S, Kennedy WA. Clinical presentation and urachal remnant pathology: implications for treatment. J Urol. 2009;182(4 Suppl):1921–4.CrossRefGoogle Scholar
  7. 7.
    Paner GP, Lopez-Beltran A, Sirohi D, Amin MB. Updates in the pathologic diagnosis and classification of epithelial neoplasms of urachal origin. Adv Anat Pathol. 2016;23:71–83.CrossRefGoogle Scholar
  8. 8.
    Ashley RA, Inman BA, Routh JC, et al. Urachal anomalies: a longitudinal study of urachal remnants in children and adults. J Urol. 2007;178:1615–8.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of PathologyEdinburgh Royal InfirmaryEdinburghUK
  2. 2.Centre for Comparative PathologyUniversity of EdinburghEdinburghUK
  3. 3.Department of Health Sciences, College of Life SciencesUniversity of Leicester, Centre for MedicineLeicesterUK

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