Choriodecidual Haemosiderin Staining

  • T. Yee Khong
  • Jerzy Stanek


Choriodecidual haemosiderin staining is defined as the presence of iron, preferably confirmed by using histochemical stains, in the amniochorial membranes or the basal plate. Placental haemosiderosis is a wider term which includes also the villous haemosiderosis. Haemosiderin staining can be graded as mild, moderate or severe, based on the extent and density of haemosiderin deposition. It is a typical association of placental chronic abruption but it can be also seen in asymptomatic patients, particularly when iron stain is used. In this latter situation, its significance and other associations remain to be determined.


Haemosiderosis Iron metabolism 


  1. 1.
    Redline RW, Wilson-Costello D. Chronic peripheral separation of placenta. The significance of diffuse chorioamnionic hemosiderosis. Am J Clin Pathol. 1999;111:804–10.CrossRefGoogle Scholar
  2. 2.
    Khong TY, Toering TJ, Erwich JJ. Haemosiderosis in the placenta does not appear to be related to chronic placental separation or adverse neonatal outcome. Pathology. 2010;42:119–24.CrossRefGoogle Scholar
  3. 3.
    Stanek J. Placental haemosiderosis. Pathology. 2010;42:499–501.CrossRefGoogle Scholar
  4. 4.
    Salafia CM, Lopez-Zeno JA, Sherer DM, et al. Histologic evidence of old intrauterine bleeding is more frequent in prematurity. Am J Obstet Gynecol. 1995;173:1065–70.CrossRefGoogle Scholar
  5. 5.
    Ohyama M, Itani Y, Yamanaka M, et al. Maternal, neonatal, and placental features associated with diffuse chorioamniotic hemosiderosis, with special reference to neonatal morbidity and mortality. Pediatrics. 2004;113:800–5.CrossRefGoogle Scholar
  6. 6.
    Stanek J, Biesiada J. Clustering of maternal-fetal clinical conditions and outcomes and placental lesions. Am J Obstet Gynecol. 2012;206:493.e1–8.CrossRefGoogle Scholar
  7. 7.
    Stanek J. Placental pathology varies in hypertensive conditions of pregnancy. Virchows Arch. 2018;472(3):415–23.CrossRefGoogle Scholar
  8. 8.
    Stanek J. Chorionic disk extravillous trophoblasts in placental diagnosis. Am J Clin Pathol. 2011;136:540–7.CrossRefGoogle Scholar
  9. 9.
    Stanek J. Acute and chronic placental membrane hypoxic lesions. Virchows Arch. 2009;455:315–22.CrossRefGoogle Scholar
  10. 10.
    Stanek J. Association of coexisting morphological umbilical cord abnormality and clinical cord compromise with hypoxic and thrombotic placental histology. Virchows Arch. 2016;468:723–32.CrossRefGoogle Scholar
  11. 11.
    Yamada S, Marutani T, Hisaoka M, et al. Pulmonary hypoplasia on preterm infant associated with diffuse chorioamniotic hemosiderosis caused by intrauterine hemorrhage due to massive subchorial hematoma: report of a neonatal autopsy case. Pathol Int. 2012;62:543–8.CrossRefGoogle Scholar
  12. 12.
    Genest DR. Estimating the time of death in stillborn fetuses: II. Histologic evaluation of the placenta; a study of 71 stillborns. Obstet Gynecol. 1992;80:585–92.PubMedGoogle Scholar
  13. 13.
    Ponka P, Lok CN. The transferrin receptor: role in health and disease. Int J Biochem Cell Biol. 1999;31:1111–37.CrossRefGoogle Scholar
  14. 14.
    Bulmer JN, Morrison L, Johnson PM. Expression of the proliferation markers Ki67 and transferrin receptor by human trophoblast populations. J Reprod Immunol. 1988;14:291–302.CrossRefGoogle Scholar
  15. 15.
    Rood KM, Buhimschi IA, Rodewald Millen K, et al. Evidence for participation of neutrophil gelatinase-associated lipocalin/matrix metalloproteinase-9 (NGAL*MMP-9) complex in the inflammatory response to infection in pregnancies complicated by preterm birth. Am J Reprod Immunol. 2016;76:108–17.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.SA Pathology, Women’s and Children’s HospitalNorth AdelaideAustralia
  2. 2.University of AdelaideAdelaideAustralia
  3. 3.Division of PathologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA

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