Amnion Transport: Histologic Features

  • Robert W. Bendon


The amnion can transport and accumulate substances from the amniotic fluid. The clinical correlation of lipid accumulation in amnion epithelium in gastroschisis and of bilirubin accumulation through the membranes in meconium passage is discussed.


Amnion Meconium Gastroschisis 


  1. 1.
    van Herendael BJ, Oberti C, Brosens I. Microanatomy of the human amniotic membranes. A light microscopic, transmission, and scanning electron microscopic study. Am J Obstet Gynecol. 1978;131:872–80.CrossRefGoogle Scholar
  2. 2.
    Wynn RM, French GL. Comparative ultrastructure of the mammalian amnion. Obstet Gynecol. 1968;31:759–74.PubMedGoogle Scholar
  3. 3.
    Carroll SG, Kuo PY, Kyle PM, Soothill PW. Fetal protein loss in gastroschisis as an explanation of associated morbidity. Am J Obstet Gynecol. 2001;184:1297–301.CrossRefGoogle Scholar
  4. 4.
    Ariel IB, Landing BH. A possibly distinctive vacuolar change of the amniotic epithelium associated with gastroschisis. Pediatr Pathol. 1985;3:283–9.CrossRefGoogle Scholar
  5. 5.
    Miller PW, Coen RW, Benirschke K. Dating the time interval from meconium passage to birth. Obstet Gynecol. 1985;66:459–62.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Bourne G. The human amnion and chorion. Chicago: Year Book Medical Publishers, Inc.; 1962.Google Scholar
  7. 7.
    Barham KA. Amnioscopy, meconium and fetal well-being. J Obstet Gynaecol Br Commonw. 1969;76:412–8.CrossRefGoogle Scholar
  8. 8.
    Funai EF, Labowsky AT, Drewes CE, Kliman HJ. Timing of fetal meconium absorption by amnionic macrophages. Am J Perinatol. 2009;26:93–7.CrossRefGoogle Scholar
  9. 9.
    Incerti M, Locatelli A, Consonni S, Bono F, Leone BE, Ghidini A. Can placental histology establish the timing of meconium passage during labor? Acta Obstet Gynecol Scand. 2011;90:863–8.CrossRefGoogle Scholar
  10. 10.
    Bendon RW. Comparison of clinical history with the depth of meconium in the fetal membranes. Mid America Placental Study Group, Sept 17, 1998; Toronto 1998.Google Scholar
  11. 11.
    Morhaime JL, Park K, Benirschke K, Baergen RN. Disappearance of meconium pigment in placental specimens on exposure to light. Arch Pathol Lab Med. 2003;127:711–4.PubMedPubMedCentralGoogle Scholar
  12. 12.
    Kudose S, Shenoy A, Krigman H. Is vacuolization in amniocytes really pathognomonic for fetal gastroschisis? Placenta. 2017;50:16–8.CrossRefGoogle Scholar
  13. 13.
    Block MF, Kallenberger DA, Kern JD, Nepveux RD. In utero meconium aspiration by the baboon fetus. Obstet Gynecol. 1981;57:37–40.PubMedGoogle Scholar
  14. 14.
    Naeye R. Can meconium in the amniotic fluid injure the fetal brain. Obstet Gynecol. 1995;86:720–4.CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Robert W. Bendon
    • 1
  1. 1.Norton Children’s HospitalLouisvilleUSA

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