Chronic deciduitis is characterized by the presence of lymphoplasmacytic inflammation or, in the absence of plasma cells, diffuse and intense (>50/HPF) non-perivascular lymphocytes in the decidua. Chronic deciduitis is one of a group of chronic placental inflammatory lesions, which include VUE and chronic chorioamnionitis. While the exact cause is not known, it is suggested that immune mechanisms related to maternal anti-fetal rejection, or alternatively, chronic microbial infection, may be involved in causation. Chronic deciduitis is an association with preterm labour. Chronic deciduitis is more frequent in chromosomally normal and abnormal spontaneous miscarriage, when compared to elective terminations, suggesting a role in first trimester pregnancy loss.
KeywordsChronic deciduitis Lymphocytes Plasma cells Preterm labour Spontaneous miscarriage Rejection
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