Chronic Histiocytic Intervillositis

  • Eoghan E. MooneyEmail author


Chronic histiocytic intervillositis (CHIV) is a rare inflammatory condition that is associated with a poor perinatal outcome, including fetal growth restriction and perinatal loss. It may recur in subsequent pregnancies. Recognition of CHIV by pathologists, and explanation of the significance of this finding to clinicians, is important in patient care.


Inflammation Intervillositis Recurrent loss Fetal growth restriction 


  1. 1.
    Labarrere C, Mullen E. Fibrinoid and trophoblastic necrosis with massive chronic intervillositis: an extreme variant of villitis of unknown etiology. Am J Reprod Immunol Microbiol. 1987;15:85–91.CrossRefGoogle Scholar
  2. 2.
    Mekinian A, Costedoat-Chalmeau N, Masseau A, et al. Chronic histiocytic intervillositis: outcome, associated diseases and treatment in a multicenter prospective study. Autoimmunity. 2015;48:40–5.CrossRefGoogle Scholar
  3. 3.
    Crawford A, Moore L, Bennett G, et al. Recurrent chronic histiocytic intervillositis with intrauterine growth restriction, osteopenia, and fractures. Am J Med Genet A. 2016;170A:2960–4.CrossRefGoogle Scholar
  4. 4.
    Dubruc E, Lebreton F, Giannoli C, et al. Placental histological lesions in fetal and neonatal alloimmune thrombocytopenia: a retrospective cohort study of 21 cases. Placenta. 2016;48:104–9.CrossRefGoogle Scholar
  5. 5.
    Jacques SM, Qureshi F. Chronic intervillositis of the placenta. Arch Pathol Lab Med. 1993;117:1032–5.PubMedGoogle Scholar
  6. 6.
    Boyd TK, Redline RW. Chronic histiocytic intervillositis: a placental lesion associated with recurrent reproductive loss. Hum Pathol. 2000;31:1389–96.CrossRefGoogle Scholar
  7. 7.
    Traeder J, Jonigk D, Feist H, et al. Pathological characteristics of a series of rare chronic histiocytic intervillositis of the placenta. Placenta. 2010;31:1116–9.CrossRefGoogle Scholar
  8. 8.
    Marchaudon V, Devisme L, Petit S, et al. Chronic histiocytic intervillositis of unknown etiology: clinical features in a consecutive series of 69 cases. Placenta. 2010;32:140–5.CrossRefGoogle Scholar
  9. 9.
    Levytska K, Higgins M, Keating S, et al. Placental pathology in relation to uterine artery Doppler findings in pregnancies with severe intrauterine growth restriction and abnormal umbilical artery Doppler changes. Am J Perinatol. 2017;34:451–7.PubMedGoogle Scholar
  10. 10.
    Bos M, Nikkels PGJ, Cohen D, et al. Towards standardised criteria for diagnosing chronic intervillositis of unknown etiology: a systematic review. Placenta. 2018;61:80–8.CrossRefGoogle Scholar
  11. 11.
    Weber M, Nikkels PGJ, Hamoen K, et al. Co-occurrence of massive perivillous fibrin deposition and chronic intervillositis: case report. Pediatr Dev Pathol. 2006;9:234–8.CrossRefGoogle Scholar
  12. 12.
    Capuani C, Meggetto F, Duga I, et al. Specific infiltration pattern of FOXP3+regulatory T cells in chronic histiocytic intervillositis of unknown etiology. Placenta. 2013;34:149–54.CrossRefGoogle Scholar
  13. 13.
    Labarrere CA, Hardin JW, Hass DM, Kassab GS. Chronic villitis of unknown etiology and massive chronic intervillositis have similar immune cell composition. Placenta. 2015;36:681–6.CrossRefGoogle Scholar
  14. 14.
    Parant O, Capdet J, Kessler S, et al. Chronic intervillositis of unknown etiology (CIUE): relation between placental lesions and perinatal outcome. Eur J Obstet Gynecol Reprod Biol. 2009;143:9–13.CrossRefGoogle Scholar
  15. 15.
    Bendon RW, Coventry S, Thompson M, et al. Significance of C4d immunostaining in placental chronic intervillositis. Pediatr Dev Pathol. 2015;18:362–8.CrossRefGoogle Scholar
  16. 16.
    Ordi J, Ismail MR, Ventura PJ, et al. Massive chronic intervillositis of the placenta associated with malaria infection. Am J Surg Pathol. 1998;22:1006–11.CrossRefGoogle Scholar
  17. 17.
    Taweesvisit M, Sukpna K, Siriaunkgul S, Thorner PS. Chronic histiocytic intervillositis with cytomegalovirus placentitis in a case of hydrops fetalis. Fetal Pediatr Pathol. 2012;31:294–400.Google Scholar
  18. 18.
    Heller DS. CD68 immunostaining in the evaluation of chronic histiocytic intervillositis. Arch Pathol Lab Med. 2012;136:657–9.CrossRefGoogle Scholar
  19. 19.
    Brito H, Juliano P, Altemani C, Altemani A. Is the immunohistochemical study of the inflammatory infiltrate helpful in distinguishing villitis of unknown etiology from non-specific infection villitis? Placenta. 2005;26:839–41.CrossRefGoogle Scholar
  20. 20.
    Reus AD, van Besouw NM, Molenaar NM, et al. An immunological basis for chronic histiocytic intervillositis in recurrent fetal loss. Am J Reprod Immunol. 2013;70:230–7.CrossRefGoogle Scholar
  21. 21.
    Downey P, Kelehan P, Mooney EE. Chronic placental intervillositis and villitis: relationship to pregnancy outcome. Virchows Arch. 2009;455(Suppl 1):S163–4. (Abstract)Google Scholar
  22. 22.
    Abdulghani S, Moretti F, Gruslin A, Grynspan D. Recurrent massive perivillous fibrin deposition and chronic intervillositis treated with heparin and intravenous immunoglobulin: a case report. J Obstet Gynaecol Can. 2017;39:676–81.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineNational Maternity HospitalDublinIreland

Personalised recommendations