Acute Villitis

  • Adrian K. CharlesEmail author


Acute inflammation involving the villi may be seen in a range of aetiologies, including infarction and necrotising chronic villitis, but acute villitis limited to acute inflammation involving villi is uncommon. It may be seen in some haematogenous infections including listeria, early phase of tuberculosis, and syphilis. It is more often seen with severe intra-amniotic infection by highly pathogenic organisms (including streptococci and Gram-negative bacilli), with secondary haematogenous spread, either in the maternal or rarely in the fetal circulation.


Placenta Villi Acute inflammation Listeria 


  1. 1.
    Matoso A, Shapiro S, De Paepe ME, Gundogan F. Placental intravascular organisms: a case report. J Perinatol. 2010;30:688–90.CrossRefGoogle Scholar
  2. 2.
    Sheikh SS, Amr SS, Lage JM. Acute placental infection due to Klebsiella pneumoniae: report of a unique case. Infect Dis Obstet Gynecol. 2005;13:49–52.CrossRefGoogle Scholar
  3. 3.
    Carmona-Fonseca J, Arango E, Maestre A. Placental malaria in Colombia: histopathologic findings in Plasmodium vivax and P. falciparum infections. Am J Trop Med Hyg. 2013;88:1093–101.CrossRefGoogle Scholar
  4. 4.
    Bae GE, Yoon N, Choi M, Hwang S, Hwang H, Kim JS. Acute placental villitis as evidence of fetal sepsis: an autopsy case report. Pediatr Dev Pathol. 2016;19:165–8.CrossRefGoogle Scholar
  5. 5.
    Abramowsky CR, Gutman J, Hilinski JA. Mycobacterium tuberculosis infection of the placenta: a study of the early (innate) inflammatory response in two cases. Pediatr Dev Pathol. 2012;15:132–6.CrossRefGoogle Scholar
  6. 6.
    Taweevisit M, Nisagornsen C, Thorner PS. Intrauterine tuberculosis manifesting as acute chorioamnionitis: a case report and review of the literature. Pediatr Dev Pathol. 2015;18:335–8.CrossRefGoogle Scholar
  7. 7.
    Genest DR, Choi-Hong SR, Tate JE, Qureshi F, Jacques SM, Crum C. Diagnosis of congenital syphilis from placental examination: comparison of histopathology, Steiner stain, and polymerase chain reaction for Treponema pallidum DNA. Hum Pathol. 1996;27:366–72.CrossRefGoogle Scholar
  8. 8.
    Qureshi F, Jacques SM, Reyes MP. Placental histopathology in syphilis. Hum Pathol. 1993;24:779–84.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Sidra MedicineDohaQatar
  2. 2.Weill Cornell Medical CollegeDohaQatar

Personalised recommendations