Fetal Vessels: Malignancy

  • Marie-Anne BründlerEmail author
  • Adrian K. Charles


Placental involvement by congenital fetal malignancies is extremely rare and associated with a high rate (90%) of stillbirth and perinatal and early infant death. Neuroblastoma is the most commonly reported type, followed by transient myeloproliferative disorder and acute leukaemia. Although not restricted to cases with placental involvement, placentomegaly with or without chorionic villous oedema and concomitant fetal hydrops are common findings in congenital fetal malignancies, particularly in neuroblastoma. Otherwise, the placenta is generally grossly unremarkable. On microscopy, involvement of fetal blood vessels by neoplastic cells is a consistent finding, whereas tumour extension into the villous stroma or perivillous space is uncommon.


Congenital fetal tumours Placental metastasis Microscopic lesions Neuroblastoma Transient abnormal myelopoiesis Stillbirth Hydrops 


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory Medicine and Paediatrics, Cumming School of MedicineUniversity of CalgaryCalgaryCanada
  2. 2.Department of Pathology and Laboratory MedicineAlberta Children’s HospitalCalgaryCanada
  3. 3.Sidra MedicineDohaQatar
  4. 4.Weill Cornell Medical CollegeDohaQatar

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