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Extramedullary Haemopoiesis

  • Luiz Cesar Peres
Chapter

Abstract

Blood cell production starts within the yolk sac during the third week of gestation, from where haematopoietic stem cells colonise the umbilical cord and aorta-gonad-mesonephros region and then the liver. By term, the bone marrow is the main site of blood cell production. Extramedullary haemopoiesis (EMH) is defined as blood cell production outside the bone marrow and, in the placenta, it happens within the villous stroma. Prolonged hypoxia and/or anaemia, usually associated with hydrops fetalis, may induce placental EMH, where a central macrophage provides the adequate microenvironment for maturation of the erythroid precursors.

Keywords

Nucleated red blood cells Extramedullary haemopoiesis Hydrops fetalis Intravascular haemopoiesis Erythroblast precursors 

References

  1. 1.
    Brugnara C, Platt OS. The neonatal erythrocyte and its disorders. In: Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE, editors. Nathan and Oski’s hematology of infancy and childhood. 7th ed. Philadelphia: Saunders Elsevier; 2009. p. 21–66.Google Scholar
  2. 2.
    Sieff CA, Zon LI. Anatomy and physiology of hematopoiesis. In: Orkin SH, Nathan DG, Ginsburg D, Look AT, Fisher DE, Lux SE, editors. Nathan and Oski’s hematology of infancy and childhood. 7th ed. Philadelphia: Saunders Elsevier; 2009. p. 195–305.Google Scholar
  3. 3.
    Tavian M, Coulombel L, Luton D, Clemente HS, Dieterlen-Lièvre F, Péault B. Aorta-associated CD34+ hematopoietic cells in the early human embryo. Blood. 1996;87:67–72.PubMedGoogle Scholar
  4. 4.
    Alvarez-Silva M, Belo-Diabanbouaya P, Salaün J, Dieterlen-Lièvre F. Mouse placenta is a major hematopoietic organ. Development. 2003;130:5437–44.CrossRefGoogle Scholar
  5. 5.
    Gekas C, Dieterlen-Lièvre F, Orkin SH, Mikkola HK. The placenta is a niche for hematopoietic stem cells. Dev Cell. 2005;8:365–75.CrossRefGoogle Scholar
  6. 6.
    Covas DT, Panepucci RA, Fontes AM, Silva WA Jr, Orellana MD, Freitas MC, et al. Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146(+) perivascular cells and fibroblasts. Exp Hematol. 2008;36:642–54.CrossRefGoogle Scholar
  7. 7.
    He S, Wang L, Pan P, Wei H, Meng D, Du J, Tian X, Zheng C, Qiu X, Luo G. Etiology and perinatal outcome of nonimmune hydrops in Southern China. AJP Rep. 2017;7:e111–5.CrossRefGoogle Scholar
  8. 8.
    Johns JL, Christopher MM. Extramedullary hematopoiesis: a new look at the underlying stem cell niche, theories of development, and occurrence in animals. Vet Pathol. 2012;49:508–23.CrossRefGoogle Scholar
  9. 9.
    Kim CH. Homeostatic and pathogenic extramedullary hematopoiesis. J Blood Med. 2010;1:13–9.CrossRefGoogle Scholar
  10. 10.
    Sandler SG, Queenan JT. A guide to terminology for Rh immunoprophylaxis. Obstet Gynecol. 2017;130:633–5.CrossRefGoogle Scholar
  11. 11.
    Gilja BK, Shah VP. Hydrops fetalis due to ABO incompatibility. Clin Pediatr (Phila). 1988;27:210–2.CrossRefGoogle Scholar
  12. 12.
    Karagol BS, Zenciroglu A, Okumus N, Karadag N, Dursun A, Hakan N. Hemolytic disease of the newborn caused by irregular blood subgroup (Kell, C, c, E, and e) incompatibilities: report of 106 cases at a tertiary-care centre. Am J Perinatol. 2012;29:449–54.CrossRefGoogle Scholar
  13. 13.
    Rogers BB, Mark Y, Oyer CE. Diagnosis and incidence of fetal parvovirus infection in an autopsy series: I.Histology. Pediatr Pathol. 1993;13:371–9.CrossRefGoogle Scholar
  14. 14.
    Jordan JA. Identification of human parvovirus B19 infection in idiopathic nonimmune hydrops fetalis. Am J Obstet Gynecol. 1996;174:37–42.CrossRefGoogle Scholar
  15. 15.
    Ravishankar S, Migliori A, Struminsky J, Has P, Sung CJ, He M. Placental findings in feto-maternal hemorrhage in livebirth and stillbirth. Pathol Res Pract. 2017;213:301–4.CrossRefGoogle Scholar
  16. 16.
    Lewis NE, Marszalek L, Ernst LM. Placental pathologic features in fetomaternal hemorrhage detected by flow cytometry. Pediatr Dev Pathol. 2017;20:142–51.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of HistopathologySheffield Children’s NHS Foundation TrustSheffieldUK
  2. 2.University of SheffieldSheffieldUK

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