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Acute Chorioamnionitis

  • Phillip CoxEmail author
  • Marta C. Cohen
  • Irene B. Scheimberg
Chapter

Abstract

Acute chorioamnionitis comprises acute inflammation of the chorionic plate of the placenta, the amniochorial membrane and umbilical cord. Most cases are the result of acute bacterial infection of the amniotic fluid/amniotic cavity, with the potential to spread to the fetus, to initiate preterm labour or to cause maternal sepsis.

In the chorionic plate, maternal and fetal components to the inflammatory response can be recognised by histological examination. Both elements can show a range of extent and severity, which should be recorded in the histology report, either descriptively or as a grade and stage.

The fetal inflammatory component has implications for a number of serious neonatal and long-term morbidities, particularly in premature infants.

Keywords

Acute chorioamnionitis Chorionic plate inflammation Infection Fetal inflammatory response Maternal inflammatory response Placenta 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Phillip Cox
    • 1
    Email author
  • Marta C. Cohen
    • 2
  • Irene B. Scheimberg
    • 3
    • 4
  1. 1.Birmingham Women’s and Children’s NHS TrustBirminghamUK
  2. 2.Sheffield Children’s Hospital NHS FTSheffieldUK
  3. 3.Queen Mary University College Medical SchoolLondonUK
  4. 4.Department of Cellular PathologyThe Royal London Hospital, Barts Health NHS TrustLondonUK

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