Peptide Synthesis Using Proteases as Catalyst

  • Sonia Barberis
  • Mauricio Adaro
  • Anabella Origone
  • Grisel Bersi
  • Fanny Guzmán
  • Andrés Illanes


Proteolytic enzymes (proteases) comprise a group of hydrolases (EC 3.4, NC-IUBMB) which share the common feature of acting on peptide bonds. Proteases are among the best-studied enzymes in terms of structure–function relationship (Krowarsch et al. 2005). Proteases, by catalyzing the cleavage of other proteins and even themselves, have an enormous physiological significance, their coding genes representing as much as 2% of the total human genome (Schilling and Overall 2008).


Bioactive peptides Therapeutic peptides Peptide vaccines cosmetic peptides Drugs carriers Nutritional peptides 


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Sonia Barberis
    • 1
    • 2
  • Mauricio Adaro
    • 1
    • 2
  • Anabella Origone
    • 1
    • 2
  • Grisel Bersi
    • 1
    • 2
  • Fanny Guzmán
    • 3
  • Andrés Illanes
    • 4
  1. 1.Laboratorio de Bromatología, Facultad de Química, Bioquímica y FarmaciaUniversidad Nacional de San LuisSan LuisArgentina
  2. 2.INFAP – CCT San Luis – CONICETSan LuisArgentina
  3. 3.Laboratorio de PéptidosNúcleo de Biotecnología Curauma, Pontificia Universidad Católica de ValparaísoValparaísoChile
  4. 4.Escuela de Ingeniería BioquímicaPontificia Universidad Católica de ValparaísoValparaísoChile

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