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Endocrine Therapy of Metastatic Breast Cancer

  • Fatma Sen
  • Adnan Aydiner
Chapter

Abstract

Endocrine treatment including medical or surgical deprivation and/or antagonism of estradiol is the mainstay of systemic treatment of patients with hormone receptor-positive (HR+) breast cancer. One third of patients with early-stage HR+ breast cancer who are treated with adjuvant endocrine treatment with curative intent will experience disease recurrence with local or distant metastasis. Additionally, approximately 5–10% of patients have distant metastasis at initial presentation. The goal of treatment in metastatic breast cancer is to improve quality of life and prolong survival. Patients with first disease recurrence and with distant metastasis should undergo a core biopsy of the site of recurrence or metastasis, which may provide new information regarding its histology, hormone receptor status, HER2 status, and proliferation/grade. Major determinants of the treatment plan include the number of lesions, extent of visceral involvement, receptor status of the primary lesion, sites of recurrence and metastasis, previous response to anticancer agents, present function of organs, performance status of patients, and social support of patients.

Keywords

Metastatic Endocrine therapy CDK4/6 inhibitor M-TOR inhibitor Aromatase inhibitor Fulvestrant Ribociclib Pablociclib Abemaciclib Everolimus 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Fatma Sen
    • 1
  • Adnan Aydiner
    • 2
  1. 1.Department of Medical OncologyAvrasya HospitalIstanbulTurkey
  2. 2.Internal Medicine, Medical Oncology, Istanbul Medical Faculty, Department of Medical Oncology, Institute of OncologyIstanbul UniversityIstanbulTurkey

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