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Preoperative Systemic Therapy for Non-Inflammatory Locally Advanced Breast Cancer

  • Serkan Keskin
  • Adnan Aydiner
Chapter

Abstract

Preoperative systemic therapy is a commonly used therapeutic approach to treat locally advanced and operable, primarily non-operable, or inflammatory breast cancer. Preoperative systemic therapy should be an option for patients who would require adjuvant systemic therapy. Neoadjuvant therapy is most appropriate for patients likely to have a good locoregional response, regardless of tumor size at presentation, including those with HER2-positive or triple-negative breast cancers. The decision regarding neoadjuvant treatment should be made after a discussion of the patient’s clinical, histological, and imaging characteristics by a multidisciplinary oncology board that includes surgical oncologists, medical oncologists, radiation oncologists, radiologists, and pathologists.

Keywords

Preoperative chemotherapy Locally advanced breast cancer Neoadjuvant chemotherapy 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Serkan Keskin
    • 1
  • Adnan Aydiner
    • 2
  1. 1.Internal Medicine, Department of Medical OncologyMemorial HospitalIstanbulTurkey
  2. 2.Internal Medicine, Medical Oncology, Istanbul Medical Faculty, Department of Medical Oncology, Institute of OncologyIstanbul UniversityIstanbulTurkey

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