Idiopathic Recurrent Acute Pericarditis

  • Apostolos KontziasEmail author


Recurrent pericarditis is idiopathic in majority of patients and is frequently precipitated by a well-defined trigger such as injury or infection. Rigorous invasive diagnostic workup is not indicated unless risk factors for secondary causes are present. Idiopathic recurrent acute pericarditis (IRAP) can rarely be complicated by myocarditis, constrictive pericarditis, and pericardial tamponade. IRAP’s pathophysiology shares features with the autoinflammatory syndromes; hence, colchicine and anakinra, an interleukin 1 receptor antagonist, have proven effective therapeutic strategies in patients refractory or intolerant to nonsteroid anti-inflammatory medications and steroids.


Recurrent pericarditis Autoinflammatory Inflammasome Colchicine Anakinra Interleukin 1 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of Rheumatology, Allergy and ImmunologyStony Brook UniversityStony BrookUSA

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