Cell Movement pp 211-258 | Cite as

Lamellipodia in Stationary and Fluctuating States

  • Danielle Holz
  • Laura M. McMillen
  • Gillian L. Ryan
  • Dimitrios VavylonisEmail author
Part of the Modeling and Simulation in Science, Engineering and Technology book series (MSSET)


We review recent mathematical models describing the diffusive transport, reaction, and turnover of actin and regulators at the leading edge of motile cells. These models are motivated by experimental results using cells with flat, steady lamellipodia studied by Single Molecule Speckle microscopy. The same cells can also be made to exhibit protruding and retracting lamellipodia, which demonstrate how changes in actin polymerization lead to changes in the rate of protrusion. The second part of this chapter provides a description of these fluctuations as an excitable actin system pushing against the cell membrane by polymerization.


Lamellipodia Leading Edge FRAP Data Fluorescence Recovery After Photobleaching (FRAP) Free Barbed Ends 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The work for this review was supported by NIH grant R01GM114201. We thank Matt Smith, Naoki Watanabe, Sawako Yamashiro, Daisuke Taniguchi, and Eric Vitriol for numerous discussions.


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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Danielle Holz
    • 1
  • Laura M. McMillen
    • 1
  • Gillian L. Ryan
    • 2
  • Dimitrios Vavylonis
    • 1
    Email author
  1. 1.Department of PhysicsLehigh UniversityBethlehemUSA
  2. 2.Department of PhysicsKettering UniversityFlintUSA

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