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Genomic Applications in Head and Neck Cancers

  • Joseph A. Bellairs
  • Jessica Yesensky
  • Jamie Ahn Ku
  • Nishant AgrawalEmail author
Chapter

Abstract

Head and neck squamous cell carcinoma (HNSCC) represents a biologically complex disease process with a heterogeneous collection of tumors in which multiple genes and pathways are altered. With the advancements in molecular and genetic research techniques and bioinformatics, there has been an explosion of new discoveries regarding the molecular biology and genetic alterations underpinning the pathogenesis of HNSCC. In this chapter, we review the specific genetic alterations in HNSCC and their clinical implications and future applications. The most common mutations in head and neck cancer, including the TP53, FAT1, NOTCH1, EGFR, HRAS, PIK3CA, and CDKN2A/p16 genes, are discussed as well as human papillomavirus as the primary etiologic agent in oropharyngeal SCC. The main topics of discussions are focused around three clinical applications of cancer genomics in head and neck cancers—diagnostic, prognostic, and therapeutic applications.

Keywords

Head and neck cancer HPV TP53 FAT1 NOTCH EGFR HRAS PIK3CA CDKN2A P16 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Joseph A. Bellairs
    • 1
  • Jessica Yesensky
    • 2
  • Jamie Ahn Ku
    • 3
  • Nishant Agrawal
    • 2
    Email author
  1. 1.Department of Otolaryngology – Head and Neck SurgeryUniversity of Washington Affiliated HospitalsSeattleUSA
  2. 2.Department of Surgery, Section of Otolaryngology – Head and Neck SurgeryUniversity of Chicago MedicineChicagoUSA
  3. 3.Head and Neck Institute, Head and Neck Surgery and OncologyCleveland Clinic Foundation and Lerner College of Medicine at Case Western Reserve UniversityClevelandUSA

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