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Cohort Studies

  • Bryan Kestenbaum
Chapter

Abstract

  1. 6.1
    Cohort studies are observational studies that are conducted in three fundamental steps:
    1. 6.1.1

      Exclude people who have the disease outcome at the start of the study

       
    2. 6.1.2

      Measure one or more exposures to define the cohorts

       
    3. 6.1.3

      Determine the incidence of the disease outcome over time 

       
     
  2. 6.2

    Ideal measurements of the exposure should be accurate, precise, equitable, and timely.

     
  3. 6.3

    Pharmacoepidemiology studies are observational studies that evaluate the consequences of medications or procedures.

     
  4. 6.4
    Analysis of cohort study data
    1. 6.4.1

      Relative risk is a ratio of disease incidences that describes risk to an individual.

       
    2. 6.4.2

      Attributable risk and population attributable risk are differences in disease incidences that describe risk to a population.

       
     
  5. 6.5
    Advantages of cohort studies include:
    1. 6.5.1

      Can discern temporal relationships between exposures and disease

       
    2. 6.5.2

      Can be used to efficiently study multiple disease outcomes

       
     
  6. 6.6
    Limitations of cohort studies include:
    1. 6.6.1

      Confounding characteristics other than the exposure of interest may bias observed associations with disease

       
    2. 6.6.2

      Inefficient design for studying rare diseases or those with long latency periods

       
     

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Bryan Kestenbaum
    • 1
  1. 1.Division of Nephrology, Department of MedicineUniversity of WashingtonSeattleUSA

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