Frailty Is Not a Fatality

  • Elisa Zengarini
  • Antonio CherubiniEmail author
Part of the Practical Issues in Geriatrics book series (PIG)


Frailty is a condition of extreme vulnerability to poor resolution of homeostasis after endogenous or exogenous stressors, which causes an increased risk of adverse health-related outcomes. Different models have been developed to operationalize frailty and standardize its diagnosis in research setting and clinical practice, but at present there is no agreed gold standard. Frailty is a common condition among older adults. Interestingly, frailty is not a static condition, but rather is a process, and as such it is dynamic and potentially reversible. In its early stages, frailty may be considered a pre-disability condition to target to prevent its progression. An effective intervention against frailty at a population level should consider a life-course approach, including also young and adult individuals with modifiable risk factors. Currently, the gold standard for the management of frailty in clinical practice is the Comprehensive Geriatric Assessment (CGA). Multiple approaches targeting frailty have been investigated. Strong evidence supports the efficacy of exercise interventions in frail older people to slow down frailty and prevent its negative consequences.


Frailty Prevention Disability Exercise Comprehensive Geriatric Assessment 


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© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Geriatria, Accettazione geriatrica e Centro di ricerca per l’invecchiamentoIRCCS-INRCAAnconaItaly

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