Regional Heterogeneity in the Regulation of Vasoconstriction in Arteries and Its Role in Vascular Mechanics
Vasoconstriction and vasodilation play important roles in the circulatory system and can be regulated through different pathways that depend on myriad biomolecules. These different pathways reflect the various functions of smooth muscle cell (SMC) contractility within the different regions of the arterial tree and how they contribute to both the mechanics and the mechanobiology. Here, we review the primary regulatory pathways involved in SMC contractility and highlight their regional differences in elastic, muscular, and resistance arteries. In this way, one can begin to assess how these properties affect important biomechanical and mechanobiological functions in the circulatory system in health and disease.
This work was supported, in part, by grants from the NIH: R01 HL105297, U01 HL116323, and R01 HL134712.
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