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Blood-Brain Barrier Integrity and Clearance of Amyloid-β from the BBB

  • Irsalan Cockerill
  • Joy-Anne Oliver
  • Huaxi Xu
  • Bingmei M. Fu
  • Donghui Zhu
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1097)

Abstract

Alzheimer’s disease, a type of dementia, affects memory, behavior, and cognitive processes in affected individuals. It is one of the prominent diseases, accounting for 60–80% of dementia cases and affecting a significant population of persons over the age of 65 years. While rare, Alzheimer’s disease (AD) may affect the younger population as well. With such a widespread number of persons affected with AD, scientists have undertaken the initiative to develop a cure for this devastating disease; however, it has been deemed quite challenging. A dysfunctional blood-brain barrier, with impaired ability to clear amyloid-β from the brain, has been directly linked to the development of Alzheimer’s disease. The blood-brain barrier restricts the flow of many substances into and out of the brain and serves as a selective and protective barrier to the brain. A proper functioning blood-brain barrier contributes to the maintenance and integrity of the brain. In turn, different systems and mechanisms within the blood-brain barrier are set in place to facilitate mediated passage of materials and substances between the brain and the bloodstream. In relation to AD, the mediation of amyloid-β clearance is of great importance in maintaining the blood-brain barrier’s integrity.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Irsalan Cockerill
    • 1
  • Joy-Anne Oliver
    • 1
  • Huaxi Xu
    • 2
    • 3
  • Bingmei M. Fu
    • 4
  • Donghui Zhu
    • 1
  1. 1.Department of Biomedical EngineeringUniversity of North TexasDentonUSA
  2. 2.Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging ResearchInstitute of Neuroscience, College of Medicine, Xiamen UniversityFujian ShengChina
  3. 3.Degenerative Diseases ProgramSanford Burnham Prebys Medical Discovery InstituteLa JollaUSA
  4. 4.Department of Biomedical EngineeringThe City College of the City University of New YorkNew YorkUSA

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