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Liver Tumours and Nodular Lesions

  • Chayarani Kelgeri
  • Khalid Sharif
  • Ulrich BaumannEmail author
Chapter

Abstract

Hepatic lesions in children can occur on a background of normal or abnormal liver parenchyma, and the differential diagnosis includes vascular malformations, benign and malignant tumours, cysts, abscesses and metastatic lesions. Understanding of radioimaging physics is pivotal in differential diagnosis and also to stage and plan surgery in symptomatic benign lesions which fail medical therapy and malignant tumours. They are best managed by a multidisciplinary team with expertise in hepatobiliary interventions. The indications of liver transplantation in hepatic lesions are spanning to include benign and some rare non-metastatic malignant lesions where complete resection is not possible. Molecular markers are under research and will add to our knowledge of tumour behaviour.

Keywords

Liver tumours Children Benign Malignant Hepatoblastoma Hepatocellular carcinoma Haemangioma Focal nodular hyperplasia Adenoma Embryonal sarcoma 

References

  1. 1.
    Adeyiga AO, Lee EY, Eisenberg RL. Focal hepatic masses in pediatric patients. Am J Roentgenol. 2012;199(4):422–40.CrossRefGoogle Scholar
  2. 2.
    Fernandez-Pineda I, Sandoval JA, Davidoff AM. Hepatic metastatic disease in pediatric and adolescent solid tumors. World Hepatol. 2015;7(14):1807–17.CrossRefGoogle Scholar
  3. 3.
    Christison-Lagay ER, Burrows PE, Alomari A, Dubois J, Kozakewich HP, Lane TS, et al. Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg. 2007;42(1):62–8.CrossRefGoogle Scholar
  4. 4.
    Latham WD. Blueberry muffin baby: neonatal neuroblastoma with subcutaneous metastases. Plast Reconstr Surg. 1971;47(1):98.CrossRefGoogle Scholar
  5. 5.
    Chunbao G, Zhang M. Liver tumors in infancy and children, hepatic surgery. 2013. https://www.intechopen.com/books/hepatic-surgery/liver-tumors-in-infancy-and-children. Accessed 4 March 2018.
  6. 6.
    Lai Q, Melandro F, Pinheiro RS, Donfrancesco A, Fadel BA, Levi Sandri GB, et al. Alpha-fetoprotein and novel tumor biomarkers as predictors of hepatocellular carcinoma recurrence after surgery: a brilliant star raises again. Int J Hepatol. 2012;2012:893103.CrossRefGoogle Scholar
  7. 7.
    Singal AK, Agarwala S. Tumour markers in pediatric solid tumours. J Indian Assoc Pediatr Surg. 2005;10(3):183–90.CrossRefGoogle Scholar
  8. 8.
    Thyagarajan MS, Sharif K. Space occupying lesions in the liver. Indian J Pediatr. 2016;83(11):1291–302.CrossRefGoogle Scholar
  9. 9.
    Sahani DV, Kalva SP. Imaging the liver. Oncologist. 2004;9(4):385–97.CrossRefGoogle Scholar
  10. 10.
    Neri E, Bali MA, Ba-Ssalamah A, Boraschi P, Brancatelli G, Alves FC, et al. ESGAR consensus statement on liver MR imaging and clinical use of liver-specific contrast agents. Eur Radiol. 2016;26(4):921–31.CrossRefGoogle Scholar
  11. 11.
    Shelmerdine SC, Roebuck DJ, Towbin AJ, McHugh K. MR of paediatric liver tumours: how we review and report. Cancer Imaging. 2016;16(1):21.CrossRefGoogle Scholar
  12. 12.
    Kulungowski AM, Alomari AI, Chawla A, Christison-Lagay ER, Fishman SJ. Lessons from a liver hemangioma registry: subtype classification. J Pediatr Surg. 2012;47(1):165–70.CrossRefGoogle Scholar
  13. 13.
    Wassef M, Blei F, Adams D, Alomari A, Baselga E, Berenstein A, et al. Vascular anomalies classification: recommendations from the International Society for the Study of Vascular Anomalies. Pediatrics. 2015;136(1):e203–15.CrossRefGoogle Scholar
  14. 14.
    Morland B, Sharif K. Primary hepatic tumors. In: Kelly DA, editor. Diseases of the liver and biliary system in children. 4th ed. West Sussex: Wiley; 2017. p. 459–78.CrossRefGoogle Scholar
  15. 15.
    Maillette de Buy Wenniger L, Terpstra V, Beuers U. Focal nodular hyperplasia and hepatic adenoma: epidemiology and pathology. Dig Surg. 2010;27(1):24–3.CrossRefGoogle Scholar
  16. 16.
    Franchi-Abella S, Branchereau S. Benign hepatocellular tumors in children: focal nodular hyperplasia and hepatocellular adenoma. Int J Hepatol. 2013;2013:1–11.CrossRefGoogle Scholar
  17. 17.
    Chung EM, Cube R, Lewis RB, Conran RM. Pediatric liver masses: radiologic-pathologic correlation. Part 1. Benign tumors. Radiographics. 2010;30(3):801–26.CrossRefGoogle Scholar
  18. 18.
    Fernandez-Pineda I, Cabello-Laureano R. Differential diagnosis and management of liver tumors in infants. World J Hepatol. 2014;6(7):486–95.CrossRefGoogle Scholar
  19. 19.
    Bahirwani R, Reddy KR. Review article: the evaluation of solitary liver masses. Aliment Pharmacol Ther. 2008;28(8):953–65.PubMedGoogle Scholar
  20. 20.
    European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines on the management of benign liver tumours. J Hepatol. 2016;65(2):386–98.CrossRefGoogle Scholar
  21. 21.
    Dhingra S, Fiel MI. Update on the new classification of hepatic adenomas. Arch Pathol Lab Med. 2014;138:1090–7.CrossRefGoogle Scholar
  22. 22.
    Calderaro J, Labrune P, Morcrette G, Rebouissou S, Franco D, Prevot S, et al. Molecular characterization of hepatocellular adenomas developed in patients with glycogen storage disease type I. J Hepatol. 2013;58(2):350–7.CrossRefGoogle Scholar
  23. 23.
    Nagarajan S, Jayabose S, McBride W, Prasadh I, Tanjavur V, Marvin MR, Rodriguez-Davalos MI. Inflammatory myofibroblastic tumor of the liver in children. J Pediatr Gastroenterol Nutr. 2013;57(3):277–80.CrossRefGoogle Scholar
  24. 24.
    Marrero JA, Ahn J, Reddy KR. ACG clinical guideline: the diagnosis and management of focal liver lesions. Am J Gastroenterol. 2014;109(9):1328–47.CrossRefGoogle Scholar
  25. 25.
    Otte JB, Pritchard J, Aronson DC, Brown J, Czauderna P, Maibach R, Maibach R, et al. Liver transplantation for hepatoblastoma: results from the International Society of Pediatric Oncology (SIOP) study SIOPEL-1 and review of the world experience. Pediatr Blood Cancer. 2004;42(1):74–83.CrossRefGoogle Scholar
  26. 26.
    Newsome JR, Venkatramani R, Heczey A, Danysh HE, Fishman DS, Miloh T. Cholangiocarcinoma among children and adolescents: a review of the literature and surveillance, epidemiology, and end results program database analysis. J Pediatr Gastroenterol Nutr. 2018;66(1):e12–8.CrossRefGoogle Scholar
  27. 27.
    López-Terrada D, Alaggio R, de Dávila MT, Czauderna P, Hiyama E, Katzenstein H, et al. Towards an international pediatric liver tumor consensus classification: proceedings of the Los Angeles COG liver tumors symposium. Mod Pathol. 2014;27(3):472–91.CrossRefGoogle Scholar
  28. 28.
    Meyers RL, Maibach R, Hiyama E, Haberle B, Krailo M, Rangaswami A, et al. Risk-stratified staging in paediatric hepatoblastoma: a unified analysis from the Children’s Hepatic Tumors International Collaboration. Lancet Oncol. 2017;18(1):122–31.CrossRefGoogle Scholar
  29. 29.
    D’Antiga L, Vallortigara F, Cillo U, Talenti E, Rugge M, Zancan L, et al. Features predicting unresectability in hepatoblastoma. Cancer. 2007;110(5):1050–8.CrossRefGoogle Scholar
  30. 30.
    McDiarmid SV. Liver transplantation for malignancies in children. Liver Transpl. 2010;16(S2):S13–21.CrossRefGoogle Scholar
  31. 31.
    Meyers RL, Tiao G, de Ville de Goyet J, Superina R, Aronson DC. Hepatoblastoma state of the art: pre-treatment extent of disease, surgical resection guidelines and the role of liver transplantation. Curr Opin Pediatr. 2014;26(1):29–36.CrossRefGoogle Scholar
  32. 32.
    Saettini F, Conter V, Provenzi M, Rota M, Giraldi E, Foglia C, et al. Is multifocality a prognostic factor in childhood hepatoblastoma? Pediatr Blood Cancer. 2014;61(9):1593–7.CrossRefGoogle Scholar
  33. 33.
    Schmid I, von Schweinitz D. Pediatric hepatocellular carcinoma: challenges and solutions. J Hepatocell Carcinoma. 2017;4:15–21.CrossRefGoogle Scholar
  34. 34.
    Khan AS, Brecklin B, Vachharajani N, Subramanian V, Nadler M, Stoll J, et al. Liver transplantation for malignant primary pediatric hepatic tumors. J Am Coll Surg. 2017;225(1):103.CrossRefGoogle Scholar
  35. 35.
    Squires RH, Ng V, Romero R, Ekong U, Hardikar W, Emres S, et al. Evaluation of the pediatric patient for liver transplantation: 2014 practice guideline by the American Association for the Study of Liver Diseases, American Society of Transplantation and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Hepatology. 2014;60(1):362–98.CrossRefGoogle Scholar
  36. 36.
    Romano F, Stroppa P, Bravi M, Casotti V, Lucianetti A, Guizzetti M, et al. Favorable outcome of primary liver transplantation in children with cirrhosis and hepatocellular carcinoma. Pediatr Transplant. 2011;15(6):573–9.Google Scholar
  37. 37.
    Yu SB, Kim HY, Eo H, Won JK, Jung SE, Park KW, et al. Clinical characteristics and prognosis of pediatric hepatocellular carcinoma. World J Surg. 2006;30(1):43–50.CrossRefGoogle Scholar
  38. 38.
    Ismail H, Broniszczak D, Kalicinski P, Markiewicz-Kijewska M, Teisseyre J, Stefanowicz M, et al. Liver transplantation in children with hepatocellular carcinoma. Do Milan criteria apply to pediatric patients? Pediatr Transplant. 2009;13:682–92.CrossRefGoogle Scholar
  39. 39.
    Vinayak R, Cruz RJ, Ranganathan S, Mohanka R, Mazariegos G, Soltys K, et al. Pediatric liver transplantation for hepatocellular cancer and rare liver malignancies: US multicenter and single-center experience (1981-2015). Liver Transpl. 2017;23(12):1577–88.CrossRefGoogle Scholar
  40. 40.
    Baumann U, Adam R, Duvoux C, Mikolajczyk R, Karam V, D’Antiga L, et al. Survival of children after liver transplantation for hepatocellular carcinoma. Liver Transpl. 2018;24(2):246–55.CrossRefGoogle Scholar
  41. 41.
    Stringer MD. The role of liver transplantation in the management of paediatric liver tumours. Ann Royal Coll Surg Engl. 2007;89(1):12–21.CrossRefGoogle Scholar
  42. 42.
    Otte JB, Meyers R. PLUTO first report. Pediatr Transplant. 2010;14(7):830–5.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Chayarani Kelgeri
    • 1
  • Khalid Sharif
    • 1
  • Ulrich Baumann
    • 1
    • 2
    Email author
  1. 1.Liver Unit and Small Bowel Transplant, Birmingham Women’s and Children’s HospitalBirminghamUK
  2. 2.Hannover Medical SchoolHannoverGermany

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