Abstract
Worldwide, there is a strong emphasis placed on precision medicine. It is defined as an entire system including preclinical research, diagnostic technology, treatment, as well as prognosis and prevention. In terms of central nervous system diseases, especially those involving vascular malfunction, efficacious preventions and treatments depend on precise early diagnosis and personalized therapeutic protocols. In this chapter, we discuss the role of the central venous system in precision medicine for acute brain injury. We cover aspects of molecular mechanisms, molecular and radiological diagnosis, and personal treatments. Precision medicine integrates scattered medical information into a relevant and useful system aimed at developing individualized therapy for every patient to optimize efficacy and prognosis. Precision medicine is a new and complex initiative in the medical community, and with regards to central venous system disorders, individualized treatment will require ongoing research and development to achieve optimal efficiency and use.
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References
Collins FS, Varmus H. A new initiative on precision medicine. N Engl J Med. 2015;372(9):793–5.
Porche DJ. Precision medicine initiative. Am J Mens Health. 2015;9(3):177.
Liebeskind DS, Feldmann E. Imaging of cerebrovascular disorders: precision medicine and the collaterome. Ann N Y Acad Sci. 2016;1366(1):40–8.
Jickling GC, Sharp FR. Biomarker panels in ischemic stroke. Stroke. 2015;46(3):915–20.
Gnanapavan S, et al. Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders. Neurology. 2014;83(13):1210–6.
Vicini P, et al. Precision medicine in the age of big data: the present and future role of large-scale unbiased sequencing in drug discovery and development. Clin Pharmacol Ther. 2016;99(2):198–207.
Chen S, et al. Venous system in acute brain injury: mechanisms of pathophysiological change and function. Exp Neurol. 2015;272:4–10.
Zhang JH, et al. The vascular neural network—a new paradigm in stroke pathophysiology. Nat Rev Neurol. 2012;8(12):711–6.
Alexander JS, et al. Venous endothelial injury in central nervous system diseases. BMC Med. 2013;11:219.
Sternberg Z. Autonomic dysfunction: a unifying multiple sclerosis theory, linking chronic cerebrospinal venous insufficiency, vitamin D(3), and Epstein-Barr virus. Autoimmun Rev. 2012;12(2):250–9.
Alexander MR, Owens GK. Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease. Annu Rev Physiol. 2012;74:13–40.
Liao YC, et al. Let-7g improves multiple endothelial functions through targeting transforming growth factor-beta and SIRT-1 signaling. J Am Coll Cardiol. 2014;63(16):1685–94.
Elton TS, et al. Regulation of the MIR155 host gene in physiological and pathological processes. Gene. 2013;532(1):1–12.
Yang P, et al. Platelet-derived growth factor receptor-beta regulates vascular smooth muscle cell phenotypic transformation and neuroinflammation after intracerebral hemorrhage in mice. Crit Care Med. 2016;44(6):e390–402.
Miyake H, et al. Post-ischemic administration of vascular endothelial growth factor inhibitor in a rat model of cerebral venous infarction. Neurol Med Chir (Tokyo). 2013;53(3):135–40.
Zhang P, et al. Treatment with edaravone attenuates ischemic brain injury and inhibits neurogenesis in the subventricular zone of adult rats after focal cerebral ischemia and reperfusion injury. Neuroscience. 2012;201:297–306.
Badaut J, Bix GJ. Vascular neural network phenotypic transformation after traumatic injury: potential role in long-term sequelae. Transl Stroke Res. 2014;5(3):394–406.
Zivadinov R, Chung CP. Potential involvement of the extracranial venous system in central nervous system disorders and aging. BMC Med. 2013;11:260.
Zetterberg H, Smith DH, Blennow K. Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood. Nat Rev Neurol. 2013;9(4):201–10.
Mondello S, et al. The challenge of mild traumatic brain injury: role of biochemical markers in diagnosis of brain damage. Med Res Rev. 2014;34(3):503–31.
Sekhon MS, et al. Optic nerve sheath diameter on computed tomography is correlated with simultaneously measured intracranial pressure in patients with severe traumatic brain injury. Intensive Care Med. 2014;40(9):1267–74.
Maissan IM, et al. Ultrasonographic measured optic nerve sheath diameter as an accurate and quick monitor for changes in intracranial pressure. J Neurosurg. 2015;123(3):743–7.
Padayachy L, et al. Pulsatile dynamics of the optic nerve sheath and intracranial pressure: an exploratory in vivo investigation. Neurosurgery. 2016;79(1):100–7.
da Costa L, et al. Temporal profile of cerebrovascular reactivity impairment, gray matter volumes, and persistent symptoms after mild traumatic head injury. Front Neurol. 2016;7:70.
Mayer AR, et al. Investigating the properties of the hemodynamic response function after mild traumatic brain injury. J Neurotrauma. 2014;31(2):189–97.
Sagoo RS, et al. Magnetic resonance investigation into the mechanisms involved in the development of high-altitude cerebral edema. J Cereb Blood Flow Metab. 2017;37(1):319–31.
Dai X, et al. High intracranial pressure induced injury in the healthy rat brain. Crit Care Med. 2016;44(8):e633–8.
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Luo, J., Chen, S., Reis, C., Zhang, J. (2019). A Movement toward Precision Medicine in Acute Brain Injury: The Role of the Cerebral Venous System. In: Lou, M., et al. Cerebral Venous System in Acute and Chronic Brain Injuries. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-319-96053-1_19
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DOI: https://doi.org/10.1007/978-3-319-96053-1_19
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