Neurovascular Network as Future Therapeutic Targets

  • Yujie Chen
  • Yang Zhang
  • Zhenni Guo
  • Ling Liu
  • Feng Gao
  • Yanfeng Lv
  • Meng Zhang
  • Xiaochuan Sun
  • Andre Obenaus
  • Yi Yang
  • Jiping Tang
  • Hua FengEmail author
  • John H. Zhang
Part of the Springer Series in Translational Stroke Research book series (SSTSR)


In recent years, endovascular treatment, including pharmaceutical drugs and intervention therapy, has become one of the most effective strategies for stroke patients. However, neurobiological and neurovascular functions, before, during and after endovascular therapy, have not been fully addressed and remain to be clarified. It is extremely important for basic neurovascular scientists and clinicians to understand the neurobiological and neurovascular fundamentals of neuroimaging mismatches and the infarct size of stroke patients, hyperperfusion or hypoperfusion after thrombolysis or thrombolectomy, and brain swelling and hemorrhage after successful thrombolectomy. These clinical mismatches and complexities after endovascular therapy are related to active tissue connections in the neurovascular network and the function of neurobiological and neurovascular components after stroke. This comprehensive review summarizes the fundamental neurobiology and neurovascular function in endovascular therapy for stroke patients, using both basic science research and clinical studies, with a focus on cerebral hemodynamics, cell energy metabolism, and neurovascular injuries such as brain swelling, hemorrhage or over-reperfusion. A major emphasis is the potential role of cerebral collateral circulation and venous circulation during and after endovascular therapy. It is clear that the cerebral hemodynamic balance, venous function, and autoregulation are all involved in endovascular therapy.


Neurovascular network Cerebral veins Stroke 



Cerebral blood flow


Cerebral blood flow


Collateral flow index


Carbon dioxide


Cerebral perfusion pressure


Computed tomography


computed tomography angiography


Computed tomography perfusion


Computed tomography venography


Digital subtraction angiography


Draining vein pressure


Diffusion weighted imaging


Echo color Doppler


Emptying gradient


Emptying time


Filling gradient


Fluid-attenuated inversion recovery


Functional micro-ultrasound


Filling time


Glasgow outcome scale


Head inflow


Head outflow


Middle cerebral artery occlusion


Magnetic resonance angiography


Magnetic resonance imaging


Magnetic resonance venography


National Institutes of Health Stroke Scale


Nitric oxide


Orthogonal polarized spectral


Platelet-derived growth factor


Platelet-derived growth factor-BB


Peroxisome proliferator-activated receptor-gamma


Relative cerebral blood flow


Relative cerebral blood volume


Reactive oxygen species


Recombinant tissue plasminogen activator


Residual volume


Single photon emission computed tomography


Superior sagittal sinus


Susceptibility weighted imaging


Vascular endothelial growth factor


Venous volume



This work was supported by the National Institutes of Health (P01 NS082184, R01 NS081740, and R01 NS091042 to John H. Zhang), the National Basic Research Program of China (973 Program, 2014CB541600 to Hua Feng), the Major Technology Innovation Project of Southwest Hospital (SWH2016ZDCX1011 to Hua Feng) and the National Natural Science Foundation of China (81220108009 to Hua Feng, 81501002 to Yujie Chen).

Conflict of Interest

The authors declare that there are no conflicts of interest.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Yujie Chen
    • 1
    • 2
    • 3
  • Yang Zhang
    • 4
  • Zhenni Guo
    • 5
  • Ling Liu
    • 6
  • Feng Gao
    • 7
  • Yanfeng Lv
    • 8
  • Meng Zhang
    • 9
  • Xiaochuan Sun
    • 10
  • Andre Obenaus
    • 3
  • Yi Yang
    • 5
  • Jiping Tang
    • 11
  • Hua Feng
    • 1
    • 3
    Email author
  • John H. Zhang
    • 11
  1. 1.Department of NeurosurgerySouthwest Hospital, Third Military Medical UniversityChongqingChina
  2. 2.Departments of Anesthesiology, Neurosurgery, Neurology and Physiology, Neuroscience Research CenterLoma Linda UniversityLoma LindaUSA
  3. 3.Department of PediatricsLoma Linda UniversityLoma LindaUSA
  4. 4.Department of Laboratory MedicineSouthwest Hospital, Third Military Medical UniversityChongqingChina
  5. 5.Department of NeurologyThe First Hospital of Jilin UniversityChangchunChina
  6. 6.Department of NeurologyThe People’s Hospital of Nanpi CountyNanpiChina
  7. 7.Department of Interventional NeurologyBeijing Tiantan Hospital, Capital Medical UniversityBeijingChina
  8. 8.Department of Interventional NeurologyThe First People’s Hospital of Shijiazhuang CityShijiazhuangChina
  9. 9.Department of NeurologyDaping Hospital, Third Military Medical UniversityChongqingChina
  10. 10.Department of NeurosurgeryThe First Affiliated Hospital of Chongqing Medical UniversityChongqingChina
  11. 11.Department of Anesthesiology and PhysiologyLoma Linda UniversityLoma LindaUSA

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