The Use and Efficacy of Transcranial Direct Current Stimulation in Individuals with Neurodegenerative Dementias

  • Annalise Rahman-Filipiak
  • Jaclyn M. Reckow
  • Adam J. Woods
  • Michael A. Nitsche
  • Benjamin M. HampsteadEmail author


This chapter reviews existing and ongoing research related to the use of transcranial direct current stimulation (tDCS) as a potential cognitive enhancement intervention in cognitively impaired individuals across a range of neurodegenerative diseases including Alzheimer’s type dementia (DAT), Parkinson’s disease dementia (PDD) or dementia with Lewy bodies (DLB), frontotemporal dementia – behavioral variant (bvFTD), and primary progressive aphasia (PPA). Methodological information, including treatment montage and session structure, efficacy/outcome, and other tDCS related details are provided for each study. While still relatively early in the clinical translation phase, tDCS appears to hold some promise in these clinical samples but considerably more work is needed to identify optimal treatment parameters as well as how these may be affected by disease severity.


Aging Dementia Alzheimer’s disease Parkinson’s disease dementia Cognition Cognitive enhancement tDCS 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Annalise Rahman-Filipiak
    • 1
    • 2
  • Jaclyn M. Reckow
    • 1
    • 2
  • Adam J. Woods
    • 3
  • Michael A. Nitsche
    • 4
    • 5
  • Benjamin M. Hampstead
    • 1
    • 2
    Email author
  1. 1.Department of Mental Health ServicesVeterans Affairs Ann Arbor Healthcare SystemsAnn ArborUSA
  2. 2.Department of PsychiatryUniversity of MichiganAnn ArborUSA
  3. 3.Center for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, College of Public Health and Health ProfessionsUniversity of FloridaGainesvilleUSA
  4. 4.Department of Psychology and NeurosciencesLeibniz Research Centre for Working Environment and Human FactorsDortmundGermany
  5. 5.University Medical Hospital BergmannsheilBochumGermany

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