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Identifying Characteristic Genes and Clustering via an Lp-Norm Robust Feature Selection Method for Integrated Data

  • Sha-Sha Wu
  • Mi-Xiao Hou
  • Jin-Xing Liu
  • Juan Wang
  • Sha-Sha Yuan
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10955)

Abstract

In bioinformatics, feature selection is a good method for dimensionality reduction and has been widely used. However, the model of traditional feature selection method: Joint Embedding Learning and Sparse Regression (JELSR), whose the error term is in the form of a square term, which leads to the algorithm becoming extremely sensitive to noise and outliers and degrading the performance of the algorithm. Considering the above problem, we propose a new robust feature selection model by adding an Lp-norm constraint on error term, and name it as RJELSR, which improves the robustness of the algorithm. And we give an efficacious optimization strategy based on the augmented Lagrange multiplier method to get the optimal results. In the experimental section, we first preprocess different cancer data to obtain the integrated data, and then apply it to our algorithm for feature selection and sample clustering. Experiments on integrated data demonstrate that the performance of our method is superior to other compared methods and the selected characteristic genes are more biologically meaningful.

Keywords

Lp-norm constraint Integrated Data Feature selection Clustering 

Notes

Acknowledgement

This work was supported in part by the NSFC under grant Nos. 61572284, 61502272, and 61701279.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Sha-Sha Wu
    • 1
  • Mi-Xiao Hou
    • 1
  • Jin-Xing Liu
    • 1
  • Juan Wang
    • 1
  • Sha-Sha Yuan
    • 1
  1. 1.School of Information Science and EngineeringQufu Normal UniversityRizhaoChina

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