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Mode of Cell Division as a Regulatory Mechanism for Lung Stem Cell Behavior Compared to Other Systems

  • Ahmed El-Hashash
Chapter

Abstract

Over the last decade, new insights have been accumulated on the cell fate, behavior, and mode of division of stem/progenitor cells in the respiratory system and many other systems. The balance between symmetric and asymmetric divisions of tissue-specific stem cells is essential for proper organ formation, development, function, and repair/regeneration and, therefore, is tightly controlled. Improper asymmetric cell division can disrupt the tightly regulated morphogenesis of organs, while uncontrolled symmetrical cell division can promote tumor formation. In this chapter, we describe recently accumulated data on the division mode (symmetric vs. asymmetric) of lung stem/progenitor cells. In addition, we describe and compare these division modes and their regulatory mechanisms between the lung and other tissue-specific stem cells in mammals and other organisms, in which these processes are well investigated.

Keywords

Lung Stem cell Cell behavior Symmetric Asymmetric Cell division Muscle stem cells Epidermal stem cells Neural stem cells 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Ahmed El-Hashash
    • 1
  1. 1.The University of Edinburgh-Zhejiang International campus (UoE-ZJU Institute), and Centre of Stem Cell and Regenerative Medicine Schools of Medicine & Basic Medicine, Zhejiang UniversityHainingChina

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