Signals and Molecular Mechanisms Controlling Lung Stem/Progenitor Cell Development and Behavior

  • Ahmed El-Hashash


Better characterization and understanding of lung-specific stem cell behavior could lead to the discovery of new restoration solutions for normal and proper lung morphogenesis, repair, and regeneration. Recent data have accumulated on the behavior of these stem and progenitor cells such as self-renewal, fate, apoptosis, and differentiation into various cell types. Furthermore, many recent studies have focused on the modes of lung stem/progenitor cell division and the regulatory mechanisms of different aspects of lung stem/progenitor cell behavior, growth, and development. In this chapter, we describe recent advances on the factors, signals, and molecular mechanisms that control the self-renewing/proliferation, growth, and fate as well as differentiation of lung stem and progenitor cells.


Lung Stem cells Cell behavior Cell fate Wnt Notch TGF Signaling pathway Numb Self-renewal Differentiation 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Ahmed El-Hashash
    • 1
  1. 1.The University of Edinburgh-Zhejiang International campus (UoE-ZJU Institute), and Centre of Stem Cell and Regenerative Medicine Schools of Medicine & Basic Medicine, Zhejiang UniversityHainingChina

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