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Role of Protein Tyrosine Phosphatases in Cancer Signaling

  • Elie Kostantin
  • Yevgen Zolotarov
  • Michel L. Tremblay
Chapter

Abstract

Protein tyrosine phosphatases (PTPs) constitute a large family of enzymes that can exert both positive and negative effects on signaling pathways. With 107 members, the PTP gene family is one of the most diverse in the mammalian genome. Since most previously described oncogenes were kinases, it was logical to postulate that PTPs would, therefore, act as tumor suppressor genes. However, it is now clear that within the PTP family there are also many pro-oncogenic enzymes. Herein, we selected five key PTPs (PTEN, SHP2, PRL, TC-PTP, PTP1B) known to modulate oncogenic signaling which are therefore of great interest as predictive markers. Despite 40 years of research since their discovery, the PTP gene family remains poorly characterized. With their increasingly recognized function in cancer cell signaling, we should expect that PTPs will be further used as biomarkers and therapeutic targets.

Keywords

PTEN SHP2 PRL TC-PTP PTP1B Biomarker 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Elie Kostantin
    • 1
  • Yevgen Zolotarov
    • 1
  • Michel L. Tremblay
    • 1
  1. 1.Department of BiochemistryGoodman Cancer Research Center, McGill UniversityMontrealCanada

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