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Protein Kinase C Signaling in Carcinogenesis

  • Thao N. D. Pham
  • Debra A. Tonetti
Chapter

Abstract

Protein kinase C (PKC) is a family of serine-threonine kinases that plays an essential role in diverse physiological processes. As such, dysregulation of these kinases results in a number of pathological conditions including cancer. Functional studies have shed light on key PKC signaling pathways that contribute to maintaining survival, growth, and metastatic potential of cancer cells. Targeting specific PKC isoforms is effective at inhibiting cancer development and progression in animal models, providing proof of concept that the members of the PKC family are potentially promising therapeutic targets. Unfortunately, to date there is limited success in generating efficacious and safe PKC modulators mainly due to the high structural conservation among PKC members. An additional challenge is effectively targeting a single PKC isoform in the context of the complex interplay among the isoforms in specific tissues and cancer subtypes. Recent findings on isoform-specific binding partners provide us with an opportunity to control the activity of a single isoform without affecting others. Moving forward, there is potential to utilize specific PKC isoforms as prognostic and predictive biomarkers to guide therapeutic choice and predict response to treatment.

Keywords

PKC Isoforms Biomarkers Kinases 

Abbreviations

AML

Acute myeloid leukemia

CSC

Cancer stem cell

DAG

Diacylglycerol

GPCR

G-protein-coupled receptor

IP3

Inositol triphosphate

PDK1

Phosphoinositide-dependent kinase-1

PKA

cAMP-dependent protein kinase

PKC

Protein kinase C

PKG

cGMP-dependent protein kinase

PLC

Phosphoinositide phospholipase C

PS

Phosphatidylserine

RTK

Receptor tyrosine kinase

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Biopharmaceutical Sciences, College of PharmacyUniversity of Illinois at ChicagoChicagoUSA

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