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Steroid Hormone and Nuclear Receptor Signaling Pathways

  • Sunil Badve
Chapter

Abstract

The steroid nuclear receptor family plays an important role in cancer. The receptors upon activation exert both genomic as well as non-genomic actions resulting in growth and survival signals. Multiple co-regulators (co-activators and co-repressors) modulate the action of these receptors making understanding the downstream effects difficult. Studies within the last decade have identified additional molecules, termed “pioneer factors,” which also play a critical role in determining the genomic actions. Several means are deployed to target these receptors in multiple cancers, particularly in breast and prostate cancer. However, resistance is common and exact mechanisms of resistance are poorly understood. Recent studies have suggested that mutations of these receptors may contribute to the resistance phenotype.

Keywords

Estrogen Progesterone Androgen Glucocorticoids Retinoic acid receptors 

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pathology and Lab MedicineIndiana University School of MedicineIndianapolisUSA

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