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Host Immune Repertoire and Infection

  • Dongni Hou
  • Jieming Qu
  • Yuanlin Song
Chapter

Abstract

The human immune repertoire is defined as the totality of T and B cells with functional diversity in the human circulatory system at any given time; this repertoire is based on the most diverse portion of T and B cell receptors known as the complementarity-determining regions (CDRs). This immune repertoire is a dynamic pool that reflects the essence of immune selectivity. This chapter focuses on the collection and implementation of high-throughput sequencing data from immune repertoires involved in infectious diseases. Specifically, this chapter will review the associated bioinformatic tools required for data processing and analysis of CDRs as well as the promise of this burgeoning field to facilitate the exploration of infection-related immune repertoires for applications involving the clinical diagnosis, treatment, and prevention of infectious diseases.

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Dongni Hou
    • 1
  • Jieming Qu
    • 2
  • Yuanlin Song
    • 1
  1. 1.Department of Pulmonary and Critical Care MedicineZhongshan Hospital, Fudan UniversityShanghaiChina
  2. 2.Department of Pulmonary and Critical Care MedicineRuijin Hospital, Shanghai Jiaotong UniversityShanghaiChina

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