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Ebola Virus Disease in the Obstetric Population

  • Colin S. Brown
  • Diana Garde
  • Emily Headrick
  • Felicity Fitzgerald
  • Andy Hall
  • Hooi-Ling Harrison
  • Naomi F. WalkerEmail author
Chapter

Abstract

The clinical management of Ebola created a significant challenge during the outbreak in West Africa, due to the paucity of previous research conducted into the optimum treatment regimen. That left many centres, to some extent, having to ‘work out’ best practice as they went along, and attempting to conduct real time prospective research. Médecins Sans Frontières (MSF) [1] were the only organization to have provided relatively in depth practical guidance prior to the outbreak and this manual was the basis of further planning between the WHO, national Ministry of Health and Sanitation in Sierra Leone, and other relevant stakeholders. Additionally, guidance changed over the epidemic as experience grew. This chapter will describe four key areas in the management of Ebola in West Africa. Firstly, it outlines the most recent WHO guidance; secondly, it looks back at how Ebola was managed in differing low and high resource settings; thirdly it outlines possible and optimal options for managing complications, paying particular attention to some of the controversies faced; fourthly it describes recent and ongoing studies into potential novel therapies that may shape future practice.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Colin S. Brown
    • 1
    • 2
    • 3
  • Diana Garde
    • 4
  • Emily Headrick
    • 4
  • Felicity Fitzgerald
    • 5
  • Andy Hall
    • 1
  • Hooi-Ling Harrison
    • 6
  • Naomi F. Walker
    • 7
    • 8
    Email author
  1. 1.King’s Sierra Leone Partnership, King’s Centre for Global Health, King’s Health Partners, King’s College LondonLondonUK
  2. 2.Department of InfectionRoyal Free London NHS Foundation TrustLondonUK
  3. 3.National Infection ServicePublic Health EnglandLondonUK
  4. 4.Partners in Health (Sierra Leone, deployed 1/2015–7/2016)BostonUSA
  5. 5.Infection, Immunity, Inflammation and Physiological MedicineUCL Great Ormond Street Institute of Child HealthLondonUK
  6. 6.King’s Sierra Leone Partnership, King’s Centre for Global Health, Weston Education CentreLondonUK
  7. 7.Department of Clinical ResearchLondon School of Hygiene and Tropical MedicineLondonUK
  8. 8.Hospital for Tropical DiseasesUniversity College London HospitalLondonUK

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