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Tissue Ischemia During Aortic Repair: The Point of View of the Perfusionist

  • De Simone FrancescoEmail author
  • Tshiombo Gianbattista
  • Colombo Elisa
Chapter

Abstract

Thoracoabdominal aortic surgery involves the cross-clamping of the descending thoracic aorta, which causes an abrupt reduction of the blood supply to both viscera and lower limbs. The reduction of blood flow induces the decrease of oxygen and substrates, which are essential for the Krebs cycle and the “respiratory chain.” It also lowers the clearance of cellular catabolites, increases the probability of bleeding disorders, and prompts the release of inflammation mediators and free radicals [1–4].

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • De Simone Francesco
    • 1
    Email author
  • Tshiombo Gianbattista
    • 2
  • Colombo Elisa
    • 3
  1. 1.Department of Extracorporeal CirculationIRCCS San Raffaele Scientific InstituteMilanItaly
  2. 2.Fondazione CariploMilanItaly
  3. 3.Vascular Surgery UnitIRCCS San Raffaele Scientific InstituteMilanItaly

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