Copper Homeostasis in Gram-Positive Bacteria

  • Marc Solioz
Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)


Copper homeostasis in Gram-positive bacteria essentially requires three components: a copper exporting ATPase (founding member CopA), a copper chaperone (founding member CopZ), and a copper-responsive regulator (founding member CopY) which regulates the expression of these functions. GSH works as a back-up protective system. These four components are also part of the more complex copper homeostatic mechanism of Gram-negative organisms, discussed in Chap.  4, but will only be discussed in detail in this Chapter. Copper reduction at the plasma membrane, which is specific to Gram-positive bacteria will also be discussed here. Finally, copper regulons, which are apparently specific to Firmicutes, are presented. Most of the findings described here derive from Enterococcus hirae and L. lactis, but other organisms are considered as necessary.


ATPase Chaperone Repressor CopA CopZ CopY Gram-positive Lactococcus Enterococcus Regulon 


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© The Author(s) 2018

Authors and Affiliations

  1. 1.Department Clinical ResearchUniversity of BernBernSwitzerland

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