MRKH Patients and Their Preparations for Uterus Transplantation
The Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is defined as a congenital aplasia of the vagina and the uterus with normal female chromosomes and normal functioning ovaries. The creation of a neovagina with a sufficient vaginal length is not only the premise for a normal sexual life of these patients but also a precedent condition when thinking about uterus transplantation as a treatment for absolute uterine infertility. The non-surgical dilation is recommended as the first-line treatment for creation of a neovagina. Alternatively, there are different options of vaginal reconstruction methods. The well-established surgical approaches can be distinguished into three techniques: intestinal vaginoplasty, graft methods, and stretching techniques. The laparoscopically assisted creation of a neovagina in a modified Vecchietti-based technique seems to be the first-choice surgical option for MRKH patients, especially when aiming for a uterus transplantation in the future. The procedure should be performed in a specialized center by experienced surgeons and patients need to be treated in a holistic approach.
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