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Lung Diseases Caused by Aspergillus and Pulmonary Eosinophilia

  • Simon P. Hart
Chapter

Abstract

Aspergillus fumigatus is the most frequent cause of fungal lung disease in humans. The spectrum of aspergillus airways disease ranges from allergic asthma characterised by an IgE-mediated immune response, to allergic bronchopulmonary aspergillosis, where additionally there is airway fungal colonisation and an IgG-mediated immune response leading to bronchiectasis and fibrosis. Chronic pulmonary aspergillosis describes syndromes with varying degrees of fungal invasion and lung destruction. Patients with local or systemic immunocompromise are at risk of locally invasive fungal disease; in its extreme form manifesting as life-threatening invasive aspergillosis in neutropenic patients. Other causes of pulmonary eosinophilia are discussed, including common drug reactions and the relatively rare acute and chronic eosinophilic pneumonias.

Keywords

Fungal infection Aspergillosis Drug reaction Allergy Eosinophils Bronchoalveolar lavage Blood count Immunoglobulin E Antifungal drug therapy Infection in immunocompromised host Aspergilloma 

References

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    Denning DW, Cadranel J, Beigelman-Aubry C, Ader F, Chakrabarti A, Blot S, et al. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J. 2016;47(1):45–68.CrossRefPubMedGoogle Scholar
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    Jeong YJ, Kim KI, Seo IJ, Lee CH, Lee KN, Kim KN, et al. Eosinophilic lung diseases: a clinical, radiologic, and pathologic overview. Radiographics. 2007;27(3):617–37. discussion 637–9.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Respiratory Research GroupHull York Medical School, Castle Hill HospitalCottinghamUK

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