Dengue: A Silent Killer, a Worldwide Threat
Nowadays, the timely and effective management of mosquito-borne diseases is a crucial public health challenge to deal with. Dengue is an emerging mosquito-borne infectious disease transmitted by Aedes species. Around 3.9 billion people from more than 128 countries were affected by dengue fever. Recent research outlined that dengue can damage the platelet, disrupting the endothelium bed and provoking immune responses, resulting in severe illness. The illness extends to other vital organs, resulting in homeostasis imbalance. Currently, no vaccines, drugs, or vector control measures showed full efficacy to prevent or manage this arbovirus threat. The present chapter discussed our knowledge about dengue basic biology, epidemiology, clinical aspects, and vector control measures. In the final section, several issues to be addressed by further research are critically analyzed.
KeywordsAedes aegypti Aedes albopictus Arbovirus Culicidae Epidemiology Invasive mosquito species Pesticides Vaccine
This work was supported by the Putra Grant, Universiti Putra Malaysia, Malaysia (9470200); the authors would like to extend their sincere appreciation to the Deanship of Scientific Research at King Saud University for its funding of this research through the Research Group Project No. RG-1435-065.
Conflict of Interest: The authors declare that there is no conflict of interest regarding the publication of this study.
- Basu A et al (2008) Dengue 2 virus inhibits in vitro megakaryocytic colony formation and induces apoptosis in thrombopoietin-inducible megakaryocytic differentiation from cord blood CD34+ cells. FEMS Immunol Med Microbiol 53(1):46–51. https://doi.org/10.1111/j.1574-695X.2008.00399.x CrossRefPubMedGoogle Scholar
- Benelli G (2018) Managing mosquitoes and ticks in a rapidly changing world – facts and trends. Saudi J Biol Sci. https://doi.org/10.1016/j.sjbs.2018.06.007
- Bhamarapravati N (1989) Hemostatic defects in dengue hemorrhagic fever. Rev Infect Dis 11:826–829. https://doi.org/10.1093/clinids/11.Supplement_4.S826 CrossRefGoogle Scholar
- Chaturvedi UC et al (1999) Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures. J Med Virol 59(3):335–340. https://doi.org/10.1002/(SICI)1096-9071(199911)59:3<335::AID-JMV13>3.0.CO;2-E CrossRefPubMedGoogle Scholar
- De Azeredo EL, Monteiro RQ, De-Oliveira Pinto LM (2015) Thrombocytopenia in dengue: Interrelationship between virus and the imbalance between coagulation and fibrinolysis and inflammatory mediators. Mediators Inflamm 2015:313842. https://doi.org/10.1155/2015/313842 CrossRefPubMedPubMedCentralGoogle Scholar
- Lai C-Y et al (2008) Antibodies to envelope glycoprotein of dengue virus during the natural course of infection are predominantly cross-reactive and recognize epitopes containing highly conserved residues at the fusion loop of domain II. J Virol 82(13):6631–6643. https://doi.org/10.1128/JVI.00316-08 CrossRefPubMedPubMedCentralGoogle Scholar
- Murphy BR, Whitehead SS (2011) Immune response to dengue virus and prospects for a vaccine. Annu Rev Immunol 29(1):587–619. https://doi.org/10.1146/annurev-immunol-031210-101315 CrossRefPubMedGoogle Scholar
- Rosen L, Drouet MT, Deubel V (1999) Detection of dengue virus RNA by reverse transcription-polymerase chain reaction in the liver and lymphoid organs but not in the brain in fatal human infection. Am J Trop Med Hyg 61(5):720–724. https://doi.org/10.4269/ajtmh.1999.61.720 CrossRefPubMedGoogle Scholar
- Shinji B (1989) Dengue virus, a flavivirus, propagates in human bone marrow progenitors and hematopoietic cell lines. Blood 74(4):1235–1240Google Scholar
- Von Hundelshausen P, Weber C (2007) Platelets as immune cells: bridging inflammation and cardiovascular disease. Circ Res 100(1):27–40. https://doi.org/10.1161/01.RES.0000252802.25497.b7 CrossRefGoogle Scholar
- WHO Initiative for Vaccine Research and World Health Organization, Department of Immunization Vaccines and Biologicals (2008) Guidelines for the clinical evaluation of dengue vaccines in endemic areas, p. 45Google Scholar
- World Health Organization (2009) Dengue: guidelines for diagnosis, treatment, prevention, and control, Special Programme for Research and Training in Tropical Diseases, p. x, 147. doi: WHO/HTM/NTD/DEN/2009.1