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Understanding Malaria Induced Red Blood Cell Deformation Using Data-Driven Lattice Boltzmann Simulations

  • Joey Sing Yee Tan
  • Gábor Závodszky
  • Peter M. A. SlootEmail author
Conference paper
First Online:
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10860)

Abstract

Malaria remains a deadly disease that affected millions of people in 2016. Among the five Plasmodium (P.) parasites which contribute to malaria diseases in humans. P. falciparum is a lethal one which is responsible for the majority of the world-wide-malaria-related deaths. Since the banana-shaped stage V gametocytes play a crucial role in disease transmission, understanding the deformation of single stage V gametocytes may offer deeper insights into the development of the disease and provide possible targets for new treatment methods. In this study we used lattice Boltzmann-based simulations to investigate the effects of the stretching forces acting on infected red blood cells inside a slit-flow cytometer. The parameters that represent the cellular deformability of healthy and malaria infected red blood cells are chosen such that they mimic the deformability of these cells in a slit-flow cytometer. The simulation results show good agreement with experimental data and allow for studying the transportation of malaria infected red blood cell in blood circulation.

Keywords

Malaria-infected red blood cells Lattice Boltzmann Stage V gametocyte 
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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Joey Sing Yee Tan
    • 1
  • Gábor Závodszky
    • 2
  • Peter M. A. Sloot
    • 1
    • 3
    • 4
    Email author
  1. 1.Complexity InstituteNanyang Technological UniversitySingaporeSingapore
  2. 2.Computational Science Laboratory, Faculty of Science, Institute for InformaticsUniversity of AmsterdamAmsterdamNetherlands
  3. 3.Computational ScienceUniversity of AmsterdamAmsterdamNetherlands
  4. 4.National Research University ITMOSt. PetersburgRussia

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