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Nontuberculous Mycobacterial Disease: An Introduction and Historical Perspective

  • David E. Griffith
Chapter
Part of the Respiratory Medicine book series (RM)

Abstract

The serious study of nontuberculous mycobacterial (NTM) disease is a recent development. Although these organisms were identified more than a century ago, it is only within the last few decades that a full appreciation of their importance as human pathogens has become evident. To a large extent, that emergence has been a consequence of new and evolving diagnostic and microbiologic technologies. Progress has also been made in the realm of NTM therapeutics, but it has unfortunately not kept pace with clinical and laboratory advances. Clinicians are all too aware of the obstacles to effective treatment of NTM disease and the limitations of current NTM therapy. Perhaps the greatest challenge is discovering and overcoming the many mechanisms of antibiotic resistance possessed by NTM. There has been remarkable progress in the diagnosis and management of NTM disease in a relatively short period of time with the promise of an accelerated pace for even more significant developments in the near future.

Keywords

Nontuberculous mycobacteria Diagnosis Treatment History 

Bibliography

  1. 1.
    Wolinsky E. Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis. 1979;119(1):107–59.Google Scholar
  2. 2.
    Runyon EH. Identification of mycobacterial pathogens utilizing colony characteristics. Am J Clin Pathol. 1970;54(4):578–86.CrossRefGoogle Scholar
  3. 3.
    Runyon EH. Atypical mycobacteria: their classification. Am Rev Respir Dis. 1965;91:288–9.PubMedGoogle Scholar
  4. 4.
    Jost KC Jr, Dunbar DF, Barth SS, Headley VL, Elliott LB. Identification of Mycobacterium tuberculosis and M. avium complex directly from smear-positive sputum specimens and BACTEC 12B cultures by high-performance liquid chromatography with fluorescence detection and computer-driven pattern recognition models. J Clin Microbiol. 1995;33(5):1270–7.PubMedPubMedCentralGoogle Scholar
  5. 5.
    Louro AP, Waites KB, Georgescu E, Benjamin WH Jr. Direct identification of Mycobacterium avium complex and Mycobacterium gordonae from MB/BacT bottles using AccuProbe. J Clin Microbiol. 2001;39(2):570–3. 8: Pauls RJ, Turenne CY, Wolfe JN, Kabani A. A high proportion of novel mycobacteria species identified by 16S rDNA analysis among slowly growing AccuProbe-negative strains in a clinical setting. Am J Clin Pathol. 2003;120(4):560–6CrossRefGoogle Scholar
  6. 6.
    Cloud JL, Carroll KC, Cohen S, Anderson CM, Woods GL. Interpretive criteria for use of AccuProbe for identification of Mycobacterium avium complex directly from 7H9 broth cultures. J Clin Microbiol. 2005;43(7):3474–8.CrossRefGoogle Scholar
  7. 7.
    Griffith DE, Brown-Elliott BA, Benwill JL, Wallace RJ Jr. Mycobacterium abscessus. “Pleased to meet you, hope you guess my name...”. Ann Am Thorac Soc. 2015;12(3):436–9.CrossRefGoogle Scholar
  8. 8.
    LPSN. bacterio.net web. List of prokaryotic names with standing in nomenclature. http://www.bacterio.net/-classification.html
  9. 9.
    Tettelin H, Davidson RM, Agrawal S, Aitken ML, Shallom S, Hasan NA, Strong M, de Moura VC, De Groote MA, Duarte RS, Hine E, Parankush S, Su Q, Daugherty SC, Fraser CM, Brown-Elliott BA, Wallace RJ Jr, Holland SM, Sampaio EP, Olivier KN, Jackson M, Zelazny AM. High-level relatedness among Mycobacterium abscessus subsp. massiliense strains from widely separated outbreaks. Emerg Infect Dis. 2014;20(3):364–71.CrossRefGoogle Scholar
  10. 10.
    Tortoli E, Kohl TA, Brown-Elliott BA, Trovato A, Leão SC, Garcia MJ, Vasireddy S, Turenne CY, Griffith DE, Philley JV, Baldan R, Campana S, Cariani L, Colombo C, Taccetti G, Teri A, Niemann S, Wallace RJ Jr, Cirillo DM. Emended description of Mycobacterium abscessus, Mycobacterium abscessus subsp. abscessus and Mycobacteriumabscessus subsp. bolletii and designation of Mycobacterium abscessus subsp. massiliense comb. nov. Int J Syst Evol Microbiol. 2016;66(11):4471–9.CrossRefGoogle Scholar
  11. 11.
    Adekambi T, Sassi M, van Ingen J, Drancourt M. Reinstating Mycobacterium massiliense and Mycobacterium bolletii as species of the Mycobacterium abscessus complex. Int J Syst Evol Microbiol. 2017;67(8):2726–30.CrossRefGoogle Scholar
  12. 12.
    van Ingen J, Kohl TA, Kranzer K, Hasse B, Keller PM, Katarzyna Szafrańska A, Hillemann D, Chand M, Schreiber PW, Sommerstein R, Berger C, Genoni M, Rüegg C, Troillet N, Widmer AF, Becker SL, Herrmann M, Eckmanns T, Haller S, Höller C, Debast SB, Wolfhagen MJ, Hopman J, Kluytmans J, Langelaar M, Notermans DW, Ten Oever J, van den Barselaar P, Vonk ABA, Vos MC, Ahmed N, Brown T, Crook D, Lamagni T, Phin N, Smith EG, Zambon M, Serr A, Götting T, Ebner W, Thürmer A, Utpatel C, Spröer C, Bunk B, Nübel U, Bloemberg GV, Böttger EC, Niemann S, Wagner D, Sax H. Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study. Lancet Infect Dis. 2017;17(10):1033–41.CrossRefGoogle Scholar
  13. 13.
    Nash KA, Brown-Elliott BA, Wallace RJ Jr. A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae. Antimicrob Agents Chemother. 2009;53(4):1367–76.CrossRefGoogle Scholar
  14. 14.
    van Ingen J, Boeree MJ, van Soolingen D, Mouton JW. Resistance mechanisms and drug susceptibility testing of nontuberculous mycobacteria. Drug Resist Updat. 2012;15(3):149–61.CrossRefGoogle Scholar
  15. 15.
    Wallace RJ Jr, Iakhiaeva E, Williams MD, Brown-Elliott BA, Vasireddy S, Vasireddy R, Lande L, Peterson DD, Sawicki J, Kwait R, Tichenor WS, Turenne C, Falkinham JO 3rd. Absence of Mycobacterium intracellulare and presence of Mycobacterium chimaera in household water and biofilm samples of patients in the United States with Mycobacterium avium complex respiratory disease. J Clin Microbiol. 2013;51(6):1747–52.CrossRefGoogle Scholar
  16. 16.
    Bryant JM, Grogono DM, Rodriguez-Rincon D, Everall I, Brown KP, Moreno P, Verma D, Hill E, Drijkoningen J, Gilligan P, Esther CR, Noone PG, Giddings O, Bell SC, Thomson R, Wainwright CE, Coulter C, Pandey S, Wood ME, Stockwell RE, Ramsay KA, Sherrard LJ, Kidd TJ, Jabbour N, Johnson GR, Knibbs LD, Morawska L, Sly PD, Jones A, Bilton D, Laurenson I, Ruddy M, Bourke S, Bowler IC, Chapman SJ, Clayton A, Cullen M, Daniels T, Dempsey O, Denton M, Desai M, Drew RJ, Edenborough F, Evans J, Folb J, Humphrey H, Isalska B, Jensen-Fangel S, Jönsson B, Jones AM, Katzenstein TL, Lillebaek T, MacGregor G, Mayell S, Millar M, Modha D, Nash EF, O’Brien C, O’Brien D, Ohri C, Pao CS, Peckham D, Perrin F, Perry A, Pressler T, Prtak L, Qvist T, Robb A, Rodgers H, Schaffer K, Shafi N, van Ingen J, Walshaw M, Watson D, West N, Whitehouse J, Haworth CS, Harris SR, Ordway D, Parkhill J, Floto RA. Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium. Science. 2016;354(6313):751–7.CrossRefGoogle Scholar
  17. 17.
    van Ingen J, Boeree MJ, Dekhuijzen PN, van Soolingen D. Environmental sources of rapid growing nontuberculous mycobacteria causing disease in humans. Clin Microbiol Infect. 2009;15(10):888–93.CrossRefGoogle Scholar
  18. 18.
    Wallace RJ Jr, Zhang Y, Brown BA, Dawson D, Murphy DT, Wilson R, Griffith DE. Polyclonal Mycobacterium avium complex infections in patients with nodular bronchiectasis. Am J Respir Crit Care Med. 1998;158(4):1235–44.CrossRefGoogle Scholar
  19. 19.
    Wallace RJ Jr, Brown-Elliott BA, McNulty S, Philley JV, Killingley J, Wilson RW, York DS, Shepherd S, Griffith DE. Macrolide/Azalide therapy for nodular/bronchiectatic mycobacterium avium complex lung disease. Chest. 2014;146(2):276–82.CrossRefGoogle Scholar
  20. 20.
    O'Brien RJ, Geiter LJ, Snider DE Jr. The epidemiology of nontuberculous mycobacterial diseases in the United States. Results from a national survey. Am Rev Respir Dis. 1987;135(5):1007–14.PubMedGoogle Scholar
  21. 21.
    O'Brien RJ. The epidemiology of nontuberculous mycobacterial disease. Clin Chest Med. 1989;10(3):407–18.PubMedGoogle Scholar
  22. 22.
    Griffith DE, Brown-Elliott BA, Wallace RJ Jr. Diagnosing nontuberculous mycobacterial lung disease. A process in evolution. Infect Dis Clin North Am. 2002;16(1):235–49.CrossRefGoogle Scholar
  23. 23.
    Diagnosis and treatment of disease caused by nontuberculous mycobacteria. Am Rev Respir Dis. 1990;142(4):940–53. Erratum in: Am Rev Respir Dis 1991 Jan;143(1):204.CrossRefGoogle Scholar
  24. 24.
    Diagnosis and treatment of disease caused by nontuberculous mycobacteria. This official statement of the American Thoracic Society was approved by the Board of Directors, March 1997. Medical section of the American Lung Association. Am J Respir Crit Care Med. 1997;156(2 Pt 2):S1–25.Google Scholar
  25. 25.
    Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, Holland SM, Horsburgh R, Huitt G, Iademarco MF, Iseman M, Olivier K, Ruoss S, von Reyn CF, Wallace RJ Jr, Winthrop K, ATS Mycobacterial Diseases Subcommittee, American Thoracic Society, Infectious Disease Society of America. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175(4):367–416. Review. Erratum in: Am J Respir Crit Care Med 2007 Apr 1;175(7):744–5. Dosage error in article text.CrossRefGoogle Scholar
  26. 26.
    Jankovic M, Sabol I, Zmak L, Jankovic VK, Jakopovic M, Obrovac M, Ticac B, Bulat LK, Grle SP, Marekovic I, Samarzija M, van Ingen J. Microbiological criteria in non-tuberculous mycobacteria pulmonary disease: a tool for diagnosis and epidemiology. Int J Tuberc Lung Dis. 2016;20(7):934–40.CrossRefGoogle Scholar
  27. 27.
    Cassidy PM, Hedberg K, Saulson A, McNelly E, Winthrop KL. Nontuberculous mycobacterial disease prevalence and risk factors: a changing epidemiology. Clin Infect Dis. 2009;49(12):e124–9.CrossRefGoogle Scholar
  28. 28.
    Winthrop KL, McNelley E, Kendall B, Marshall-Olson A, Morris C, Cassidy M, Saulson A, Hedberg K. Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health disease. Am J Respir Crit Care Med. 2010;182(7):977–82.CrossRefGoogle Scholar
  29. 29.
    Winthrop KL, Varley CD, Ory J, Cassidy PM, Hedberg K. Pulmonary disease associated with nontuberculous mycobacteria, Oregon, USA. Emerg Infect Dis. 2011;17(9):1760–1.CrossRefGoogle Scholar
  30. 30.
    Henkle E, Hedberg K, Schafer S, Novosad S, Winthrop KL. Population-based incidence of pulmonary nontuberculous mycobacterial disease in Oregon 2007 to 2012. Ann Am Thorac Soc. 2015;12(5):642–7.CrossRefGoogle Scholar
  31. 31.
    Adjemian J, Olivier KN, Seitz AE, Holland SM, Prevots DR. Prevalence of nontuberculous mycobacterial lung disease in U.S. Medicare beneficiaries. Am J Respir Crit Care Med. 2012;185(8):881–6.CrossRefGoogle Scholar
  32. 32.
    Prevots DR, Shaw PA, Strickland D, Jackson LA, Raebel MA, Blosky MA, Montes de Oca R, Shea YR, Seitz AE, Holland SM, Olivier KN. Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems. Am J Respir Crit Care Med. 2010;182(7):970–6.CrossRefGoogle Scholar
  33. 33.
    Hoefsloot W, van Ingen J, Andrejak C, Angeby K, Bauriaud R, Bemer P, Beylis N, Boeree MJ, Cacho J, Chihota V, Chimara E, Churchyard G, Cias R, Daza R, Daley CL, Dekhuijzen PN, Domingo D, Drobniewski F, Esteban J, Fauville-Dufaux M, Folkvardsen DB, Gibbons N, Gómez-Mampaso E, Gonzalez R, Hoffmann H, Hsueh PR, Indra A, Jagielski T, Jamieson F, Jankovic M, Jong E, Keane J, Koh WJ, Lange B, Leao S, Macedo R, Mannsåker T, Marras TK, Maugein J, Milburn HJ, Mlinkó T, Morcillo N, Morimoto K, Papaventsis D, Palenque E, Paez-Peña M, Piersimoni C, Polanová M, Rastogi N, Richter E, Ruiz-Serrano MJ, Silva A, da Silva MP, Simsek H, van Soolingen D, Szabó N, Thomson R, Tórtola Fernandez T, Tortoli E, Totten SE, Tyrrell G, Vasankari T, Villar M, Walkiewicz R, Winthrop KL, Wagner D, Nontuberculous Mycobacteria Network European Trials Group. The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study. Eur Respir J. 2013;42(6):1604–13.CrossRefGoogle Scholar
  34. 34.
    Ito Y, Hirai T, Fujita K, Maekawa K, Niimi A, Ichiyama S, Mishima M. Increasing patients with pulmonary Mycobacterium avium complex disease and associated underlying diseases in Japan. J Infect Chemother. 2015;21(5):352–6.CrossRefGoogle Scholar
  35. 35.
    Hu P, Bai L, Liu F, Ou X, Zhang Z, Yi S, Chen Z, Gong D, Liu B, Guo J, Tan Y. Evaluation of the Xpert MTB/RIF assay for diagnosis of tuberculosis and rifampin resistance in county-level laboratories in Hunan province, China. Chin Med J (Engl). 2014;127(21):3744–5025.Google Scholar
  36. 36.
    Wu J, Zhang Y, Li J, Lin S, Wang L, Jiang Y, Pan Q, Shen X. Increase in nontuberculous mycobacteria isolated in Shanghai, China: results from a population-based study. PLoS One. 2014;9(10):e109736.CrossRefGoogle Scholar
  37. 37.
    Shao Y, Chen C, Song H, Li G, Liu Q, Li Y, Zhu L, Martinez L, Lu W. The epidemiology and geographic distribution of nontuberculous mycobacteria clinical isolates from sputum samples in the eastern region of China. PLoS Negl Trop Dis. 2015;9(3):e0003623.CrossRefGoogle Scholar
  38. 38.
    Wendt SL, George KL, Parker BC, Gruft H, Falkinham JO 3rd. Epidemiology of infection by nontuberculous mycobacteria. III. Isolation of potentially pathogenic mycobacteria from aerosols. Am Rev Respir Dis. 1980;122(2):259–63.Google Scholar
  39. 39.
    Collins CH, Grange JM, Yates MD. Mycobacteria in water. J Appl Bacteriol. 1984;57(2):193–211.CrossRefGoogle Scholar
  40. 40.
    Parker BC, Ford MA, Gruft H, Falkinham JO 3rd. Epidemiology of infection by nontuberculous mycobacteria. IV. Preferential aerosolization of Mycobacterium intracellulare from natural waters. Am Rev Respir Dis. 1983;128(4):652–6.Google Scholar
  41. 41.
    Meissner PS, Falkinham JO 3rd. Plasmid DNA profiles as epidemiological markers for clinical and environmental isolates of Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum. J Infect Dis. 1986;153(2):325–31.CrossRefGoogle Scholar
  42. 42.
    Fujita K, Ito Y, Hirai T, Maekawa K, Imai S, Tatsumi S, Niimi A, Iinuma Y, Ichiyama S, Mishima M. Genetic relatedness of Mycobacterium avium-intracellulare complex isolates from patients with pulmonary MAC disease and their residential soils. Clin Microbiol Infect. 2013;19(6):537–41.CrossRefGoogle Scholar
  43. 43.
    Falkinham JO 3rd. Environmental sources of nontuberculous mycobacteria. Clin Chest Med. 2015;36(1):35–41.CrossRefGoogle Scholar
  44. 44.
    Iseman MD, Corpe RF, O'Brien RJ, Rosenzwieg DY, Wolinsky E. Disease due to Mycobacterium avium-intracellulare. Chest. 1985;87(2 Suppl):139S–49S.CrossRefGoogle Scholar
  45. 45.
    Prince DS, Peterson DD, Steiner RM, Gottlieb JE, Scott R, Israel HL, Figueroa WG, Fish JE. Infection with Mycobacterium avium complex in patients without predisposing conditions. N Engl J Med. 1989;321(13):863–8.CrossRefGoogle Scholar
  46. 46.
    Szymanski EP, Leung JM, Fowler CJ, Haney C, Hsu AP, Chen F, Duggal P, Oler AJ, McCormack R, Podack E, Drummond RA, Lionakis MS, Browne SK, Prevots DR, Knowles M, Cutting G, Liu X, Devine SE, Fraser CM, Tettelin H, Olivier KN, Holland SM. Pulmonary nontuberculous mycobacterial infection. A multisystem, multigenic disease. Am J Respir Crit Care Med. 2015;192(5):618–28.CrossRefGoogle Scholar
  47. 47.
    Chen F, Szymanski EP, Olivier KN, Liu X, Tettelin H, Holland SM, Duggal P. Whole exome sequencing identify the 6q12-q16 linkage region and a candidate gene TTK for pulmonary nontuberculous mycobacterial disease. Am J Respir Crit Care Med. 2017;196:1599.CrossRefGoogle Scholar
  48. 48.
    Holland SM, Pierce VM, Shailam R, Glomski K, Farmer JR. Case 28-2017. A 13-month-old girl with pneumonia and a 33-year-old woman with hip pain. N Engl J Med. 2017;377(11):1077–91.CrossRefGoogle Scholar
  49. 49.
    Horsburgh CR Jr, Mason UG 3rd, Heifets LB, Southwick K, Labrecque J, Iseman MD. Response to therapy of pulmonary Mycobacterium avium-intracellulare infection correlates with results of in vitro susceptibility testing. Am Rev Respir Dis. 1987;135(2):418–21.PubMedGoogle Scholar
  50. 50.
    Research Committee of the British Thoracic Society. First randomised trial of treatments for pulmonary disease caused by M avium intracellulare, M malmoense, and M xenopi in HIV negative patients: rifampicin, ethambutol and isoniazid versus rifampicin and ethambutol. Thorax. 2001;56(3):167–72.Google Scholar
  51. 51.
    Hawkins CC, Gold JW, Whimbey E, Kiehn TE, Brannon P, Cammarata R, Brown AE, Armstrong D. Mycobacterium avium complex infections in patients with the acquired immunodeficiency syndrome. Ann Intern Med. 1986;105(2):184–8.CrossRefGoogle Scholar
  52. 52.
    Mycobacterioses and the acquired immunodeficiency syndrome. Joint position paper of the American Thoracic Society and the Centers for Disease Control. Am Rev Respir Dis. 1987;136(2):492–6.Google Scholar
  53. 53.
    Horsburgh CR Jr, Selik RM. The epidemiology of disseminated nontuberculous mycobacterial infection in the acquired immunodeficiency syndrome (AIDS). Am Rev Respir Dis. 1989;139(1):4–7.CrossRefGoogle Scholar
  54. 54.
    Chin DP, Reingold AL, Stone EN, Vittinghoff E, Horsburgh CR Jr, Simon EM, Yajko DM, Hadley WK, Ostroff SM, Hopewell PC. The impact of Mycobacterium avium complex bacteremia and its treatment on survival of AIDS patients--a prospective study. J Infect Dis. 1994;170(3):578–84.CrossRefGoogle Scholar
  55. 55.
    Shafran SD, Singer J, Zarowny DP, Phillips P, Salit I, Walmsley SL, Fong IW, Gill MJ, Rachlis AR, Lalonde RG, Fanning MM, Tsoukas CM. A comparison of two regimens for the treatment of Mycobacterium avium complex bacteremia in AIDS: rifabutin, ethambutol, and clarithromycin versus rifampin, ethambutol, clofazimine, and ciprofloxacin. Canadian HIV Trials Network Protocol 010 Study Group. N Engl J Med. 1996;335(6):377–83.CrossRefGoogle Scholar
  56. 56.
    Chaisson RE, Keiser P, Pierce M, Fessel WJ, Ruskin J, Lahart C, Benson CA, Meek K, Siepman N, Craft JC. Clarithromycin and ethambutol with or without clofazimine for the treatment of bacteremic Mycobacterium avium complex disease in patients with HIV infection. AIDS. 1997;11(3):311–7. PubMed PMID: 9147422.CrossRefGoogle Scholar
  57. 57.
    Wallace RJ Jr, Brown BA, Griffith DE, Girard WM, Murphy DT. Clarithromycin regimens for pulmonary Mycobacterium avium complex. The first 50 patients. Am J Respir Crit Care Med. 1996;153(6 Pt 1):1766–72.CrossRefGoogle Scholar
  58. 58.
    Wallace RJ Jr, Brown BA, Griffith DE, Girard WM, Murphy DT, Onyi GO, Steingrube VA, Mazurek GH. Initial clarithromycin monotherapy for Mycobacterium avium-intracellulare complex lung disease. Am J Respir Crit Care Med. 1994;149(5):1335–41.CrossRefGoogle Scholar
  59. 59.
    Griffith DE, Brown BA, Girard WM, Murphy DT, Wallace RJ Jr. Azithromycin activity against Mycobacterium avium complex lung disease in patients who were not infected with human immunodeficiency virus. Clin Infect Dis. 1996;23(5):983–9.CrossRefGoogle Scholar
  60. 60.
    Jeong BH, Jeon K, Park HY, Kim SY, Lee KS, Huh HJ, Ki CS, Lee NY, Shin SJ, Daley CL, Koh WJ. Intermittent antibiotic therapy for nodular bronchiectatic Mycobacterium avium complex lung disease. Am J Respir Crit Care Med. 2015;191(1):96–103.CrossRefGoogle Scholar
  61. 61.
    Kobashi Y, Abe M, Mouri K, Obase Y, Miyashita N, Oka M. Clinical usefulness of combination chemotherapy for pulmonary Mycobacterium avium complex disease. J Infect. 2010;Google Scholar
  62. 62.
    Kobashi Y, Matsushima T. The microbiological and clinical effects of combined therapy according to guidelines on the treatment of pulmonary Mycobacterium avium complex disease in Japan – including a follow-up study. Respiration. 2007;74(4):394–400.CrossRefGoogle Scholar
  63. 63.
    Olivier KN, Griffith DE, Eagle G, JP MG 2nd, Micioni L, Liu K, Daley CL, Winthrop KL, Ruoss S, Addrizzo-Harris DJ, Flume PA, Dorgan D, Salathe M, Brown-Elliott BA, Gupta R, Wallace RJ Jr. Randomized trial of liposomal amikacin for inhalation in nontuberculous mycobacterial lung disease. Am J Respir Crit Care Med. 2017;195(6):814–23.CrossRefGoogle Scholar
  64. 64.
    Griffith DE, Eagle G, Thomson RM, Aksamit TA, Hasegawa N, Morimoto K et al. Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex. Am J Respir and Crit Care Med, In Press, 2018.Google Scholar
  65. 65.
    van Ingen J, Ferro BE, Hoefsloot W, Boeree MJ, van Soolingen D. Drug treatment of pulmonary nontuberculous mycobacterial disease in HIV-negative patients: the evidence. Expert Rev Anti Infect Ther. 2013;11(10):1065–77.CrossRefGoogle Scholar
  66. 66.
    Brown-Elliott BA, Nash KA, Wallace RJ Jr. Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria. Clin Microbiol Rev. 2012;25(3):545–82.CrossRefGoogle Scholar
  67. 67.
    Brown-Elliott BA, Iakhiaeva E, Griffith DE, Woods GL, Stout JE, Wolfe CR, Turenne CY, Wallace RJ Jr. In vitro activity of amikacin against isolates of Mycobacterium avium complex with proposed MIC breakpoints and finding of a 16S rRNA gene mutation in treated isolates. J Clin Microbiol. 2013;51(10):3389–94.CrossRefGoogle Scholar
  68. 68.
    Griffith DE, Brown-Elliott BA, Langsjoen B, Zhang Y, Pan X, Girard W, Nelson K, Caccitolo J, Alvarez J, Shepherd S, Wilson R, Graviss EA, Wallace RJ Jr. Clinical and molecular analysis of macrolide resistance in Mycobacterium avium complex lung disease. Am J Respir Crit Care Med. 2006;174(8):928–34.CrossRefGoogle Scholar
  69. 69.
    Adjemian J, Prevots DR, Gallagher J, Heap K, Gupta R, Griffith D. Lack of adherence to evidence-based treatment guidelines for nontuberculous mycobacterial lung disease. Ann Am Thorac Soc. 2014;11(1):9–16.CrossRefGoogle Scholar
  70. 70.
    van Ingen J, Wagner D, Gallagher J, Morimoto K, Lange C, Haworth CS, Floto RA, Adjemian J, Prevots DR, Griffith DE, NTM-NET. Poor adherence to management guidelines in nontuberculous mycobacterial pulmonary diseases. Eur Respir J. 2017;49(2). pii: 1601855.Google Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.University of Texas Health Science CenterTylerUSA

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