Advances in the Treatment of Metastatic Renal Cell Carcinoma

  • Paulo Bergerot
  • Kathy Burns
  • Dhruv Prajapati
  • Rachel Fox
  • Meghan Salgia
  • Sumanta K. PalEmail author
Part of the Cancer Treatment and Research book series (CTAR, volume 175)


The treatment landscape for metastatic renal cell carcinoma has constantly been in flux. In 2005, with the advent of vascular endothelial growth factor (VEGF) tyrosine kinase inhibitor (TKI) therapy, the standard of care shifted to agents such as sunitinib and pazopanib. However, more recently there have been datasets, suggesting that next-generation TKIs such as cabozantinib may play an important role in therapy. Furthermore, immunotherapy has had resurgence with the FDA approval of nivolumab with ipilimumab. In the current chapter, we attempt to contextualize available frontline therapies for metastatic renal cell carcinoma with a focus on the CABOSUN and CheckMate 214 clinical trials.


CheckMate 214 CABOSUN Metastatic 




Conflict of Interest SKP declares consulting agreements with Genentech, Roche, Exelixis, BMS, Ipsen, Novartis, Astellas, Eisai and Pfizer.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Paulo Bergerot
    • 1
  • Kathy Burns
    • 1
  • Dhruv Prajapati
    • 1
  • Rachel Fox
    • 1
  • Meghan Salgia
    • 1
  • Sumanta K. Pal
    • 1
    Email author
  1. 1.Department of Medical Oncology and Therapeutics ResearchCity of Hope Comprehensive Cancer CenterDuarteUSA

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