Renal Mechanisms and Heart Failure

  • Bojan Jelaković
  • Vedran Premužić
  • Ana Jelaković
  • Davor Miličić
Part of the Updates in Hypertension and Cardiovascular Protection book series (UHCP)


Chronic kidney disease is an established cardiovascular risk factor, and renal dysfunction is one of the most important independent risk factors for poor outcomes and all-cause mortality in patients with heart failure. The mechanisms by which the onset of acute heart failure or acutely decompensated chronic heart failure leads to worsening renal function are multiple and complex, being different in acute versus chronic heart failure. In opposite way, multiple mechanisms are involved in deterioration of heart function in patients with impaired renal function. Cardiac and renal diseases commonly present in the same patient have been associated with increased cost of care, complications, and mortality. Importantly, worsening renal function and chronic kidney disease are the most important causes of “therapeutic nihilism” in HF patients.


Chronic kidney disease Renal function Cardiovascular risk Heart failure 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Bojan Jelaković
    • 1
  • Vedran Premužić
    • 1
  • Ana Jelaković
    • 1
  • Davor Miličić
    • 2
  1. 1.Department of Nephrology, Hypertension, Dialysis and TransplantationSchool of Medicine University od Zagreb, University Hospital Centre ZagrebZagrebCroatia
  2. 2.Cardiology Clinic, School of Medicine University of ZagrebUniversity Hospital Centre ZagrebZagrebCroatia

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