Fibroepithelial Lesions of the Breast
Fibroepithelial lesions of the breast are a group of biphasic neoplasms, lesions characterized by proliferation of both mesenchymal and epithelial elements. On the whole, these lesions constitute one of the most commonly encountered neoplasms in routine practice and span the spectrum of biological significance from benign to malignant. Prototypic examples of these neoplasms include the fibroadenoma (FA) and phyllodes tumor (PT), with the phyllodes tumor requiring further subtyping into benign, borderline/intermediate, and malignant in accordance with the World Health Organization (WHO) recommendations . These specific lesions within this group have diverse clinical behavior, natural history, and therapeutic implications, despite showing considerable morphologic overlap at times. Since many of the initial diagnoses are rendered in core biopsies, this can potentially compound a diagnostic challenge, and clinical-pathological correlation is imperative. Here, we present a review of fibroepithelial lesions with an emphasis on morphology and distinguishing features. Hamartomas, also considered a fibroepithelial lesion, is discussed below under the differential diagnosis section of fibroadenoma.
KeywordsFibroepithelial lesion Fibroadenoma Phyllodes Hamartoma Breast fibroepithelial lesions Fibroadenoma Phyllodes tumor Differential diagnosis
- 1.Tan P, Tse G, Lee A, Simpson J, Hanby A. Fibroepithelial tumors. In: Lakhani S, Ellis I, Schnitt S, Tan P, van de Vijver M, editors. WHO classifications of tumors of the breast. 4th ed. Lyon: IARC Press; 2012. p. 142–7.Google Scholar
- 12.Sanders M, Brooks J, Palazzo J. Mesenchymal lesions of the breast. In: Palazzo JP, editor. Difficult diagnoses in breast pathology. New York, NY: Demos Medical; 2011. p. 172–95.Google Scholar
- 25.Van Osdol AD, Landercasper J, Andersen JJ, Ellis RL, Gensch EM, Johnson JM, et al. Determining whether excision of all fibroepithelial lesions of the breast is needed to exclude phyllodes tumor: upgrade rate of fibroepithelial lesions of the breast to phyllodes tumor. JAMA Surg. 2014;149(10):1081–5.CrossRefPubMedGoogle Scholar