Fibroepithelial Lesions of the Breast

  • Danielle Fortuna
  • Adam Toll
  • Juan P. PalazzoEmail author


Fibroepithelial lesions of the breast are a group of biphasic neoplasms, lesions characterized by proliferation of both mesenchymal and epithelial elements. On the whole, these lesions constitute one of the most commonly encountered neoplasms in routine practice and span the spectrum of biological significance from benign to malignant. Prototypic examples of these neoplasms include the fibroadenoma (FA) and phyllodes tumor (PT), with the phyllodes tumor requiring further subtyping into benign, borderline/intermediate, and malignant in accordance with the World Health Organization (WHO) recommendations [1]. These specific lesions within this group have diverse clinical behavior, natural history, and therapeutic implications, despite showing considerable morphologic overlap at times. Since many of the initial diagnoses are rendered in core biopsies, this can potentially compound a diagnostic challenge, and clinical-pathological correlation is imperative. Here, we present a review of fibroepithelial lesions with an emphasis on morphology and distinguishing features. Hamartomas, also considered a fibroepithelial lesion, is discussed below under the differential diagnosis section of fibroadenoma.


Fibroepithelial lesion Fibroadenoma Phyllodes Hamartoma Breast fibroepithelial lesions Fibroadenoma Phyllodes tumor Differential diagnosis 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Department of PathologySt. Luke’s University Health NetworkBethlehemUSA
  3. 3.Department of PathologyThomas Jefferson University HospitalPhiladelphiaUSA

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