Atypical Lobular Hyperplasia and Lobular Carcinoma In Situ

  • Isabel Alvarado-Cabrero


Despite the earlier description by Ewing [1], the term lobular carcinoma is largely credited to Foote and Stewart [2] who, in 1941, published their seminal paper describing a detailed morphologic analysis of a distinctive subgroup of in situ carcinoma of the breast. Almost 40 years after the first description of lobular carcinoma in situ (LCIS), Haagensen et al. [3] published their own experience with this disease and concluded that “lobular neoplasia” was a more appropriate term for this lesion, as few cases appeared to progress to invasive carcinoma. With increasing recognition of LCIS, it became apparent that less well-developed forms were more frequently seen in the breast. Page et al. [4] used the term atypical lobular hyperplasia for these lesions.


Atypical lobular hyperplasia Lobular carcinoma in situ Morphological features 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Isabel Alvarado-Cabrero
    • 1
  1. 1.Department of Pathology, Hospital de Oncologia, Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico CityMexico

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