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Histology of the Normal Breast, Normal Changes, and Abnormalities of Breast Development

  • Simona Stolnicu
Chapter

Abstract

The breast, a modified sweat gland and target for different hormones, lies on the anterior chest wall over the pectoralis major muscle and has the specialized function of feeding the newborn infant. The breast displays various morphologic alteration throughout the reproductive life cycle (menarche, pregnancy, lactation, and menopause, in addition to maternal hormonal effects in utero). By understanding its normal morphology, normal changes, and immunohistochemical profile, breast pathologists are better able to identify and diagnose breast lesions, also by using ancillary examinations. A variety of abnormalities can occur during the development of the breast, most of which can be easily corrected with the help of cosmetic surgery.

Keywords

Histology Breast Immunohistochemical stains 

References

  1. 1.
    Schnitt SJ, Collins L. Biopsy interpretation of the breast. Philadelphia, PA: Lippincott Williams and Wilkins; 2009. p. 1.Google Scholar
  2. 2.
    Giacometti L, Montagna W. The nipple and the areola of the human female breast. Anat Rec. 1962;144:191–7.CrossRefGoogle Scholar
  3. 3.
    Stirling JW, Chandler JA. The fine structure of ducts and subareolar ducts in the resting gland of the female breast. Virchow Arch. 1977;373:119–32.CrossRefGoogle Scholar
  4. 4.
    Catalano PM, Ioannides G. Areolar sebaceous hyperplasia. J Am Acad Dermatol. 1985;13:867–8.CrossRefGoogle Scholar
  5. 5.
    Chiriac A, Moldovan C, Coros MF, Podoleanu C, Moncea D, Stolnicu S. Bilateral areolar sebaceous hyperplasia in a post-menopausal woman. Eur J Dermatol. 2016;26(3):299–300.PubMedGoogle Scholar
  6. 6.
    Cserni G. Benign apocrine papillary lesions of the breast lacking or virtually lacking myoepithelial cells—potential pitfalls in diagnosing malignancy. APMIS. 2012;120(3):249–52.CrossRefGoogle Scholar
  7. 7.
    Rosen PP. Rosen’s breast pathology. Philadelphia, PA: Lippincott Williams and Wilkins; 2009. p. 8.Google Scholar
  8. 8.
    Moinfar F. Essentials of diagnostic breast pathology. New York, NY: Springer; 2007. p. 236.Google Scholar
  9. 9.
    Tavassoli FA. Pathology of the breast. New York, NY: McGraw-Hill; 1999.Google Scholar
  10. 10.
    Rees TD. Mammary asymmetry. Clin Plast Surg. 1975;2:371–4.PubMedGoogle Scholar
  11. 11.
    Zilli L, Stefani G. Unilateral agenesis of the pectoralis muscle associated with mammary hypoplasia. Friuli Med. 1960;15:1522–30.PubMedGoogle Scholar
  12. 12.
    Breslau-Siderius EJ, Toonstra J, Baart JA, Koppeschar HP, Maassen JA, Beemer FA. Ectodermal dysplasia, lipoatrophy, diabetes mellitus and amastia. A second case of AREDYLD syndrome. Am J Med Genet. 1992;44:374–7.CrossRefGoogle Scholar
  13. 13.
    Trier WC. Complete breast absence. Case report and review of the literature. Plast Reconstr Surg. 1965;36:431–9.CrossRefGoogle Scholar
  14. 14.
    Wolf Y, Pauzner D, Groutz A, Walman I, David MP. Gigantomastia complicating pregnancy. Case report and review of the literature. Acta Obstet Gynecol Scand. 1995;74:159–63.CrossRefGoogle Scholar
  15. 15.
    Lui A, Karter D, Turett G. Another case of breast hypertrophy in a patient treated with indinavir. Clin Infect Dis. 1998;26:1482.CrossRefGoogle Scholar
  16. 16.
    Levy RL. Adenocarcinoma of the mammary chain. Breast Dis. 1994;7:383–6.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Simona Stolnicu
    • 1
  1. 1.Department of PathologyUniversity of Medicine and PharmacyTîrgu MureșRomania

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