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The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease

  • Francesco Russo
  • Federico De Masi
  • Søren Brunak
  • Kirstine Belling
Chapter
Part of the RNA Technologies book series (RNATECHN)

Abstract

Non-coding RNAs (ncRNAs) represent key molecular players in biological processes and human disease. Several ncRNA types have been discovered including microRNAs (miRNAs) of around 23 nucleotides and long non-coding RNAs (lncRNAs) that are above 200 nucleotides in length. One of the first functional ncRNAs discovered was the lncRNA named X inactive specific transcript (XIST). XIST is the main actor in a fundamental process called X chromosome inactivation (XCI) where, in females, one of the two X chromosomes is silenced to balance the extra gene expression dosage. In this book chapter, we present the emerging evidence for the importance of XCI in diseases such as gastric and bladder cancer and genetic pathologies such as Klinefelter (47,XXY) and Turner (45,X0) syndromes. Furthermore, a new role for the crosstalk between XIST and miRNAs is discussed. Finally, new evidence for sex bias of XCI in human tissues and development of cancer is presented.

Keywords

Non-coding RNAs X chromosome inactivation Human disease Aneuploidies Cancer Comorbidities 

Notes

Acknowledgements

We would like to thank the Novo Nordisk Foundation for supporting our research (grant agreement NNF14CC0001).

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Francesco Russo
    • 1
  • Federico De Masi
    • 2
  • Søren Brunak
    • 1
  • Kirstine Belling
    • 1
  1. 1.Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark
  2. 2.Intomics A/SLyngby (Copenhagen)Denmark

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