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Outcomes of Different Antihypertensive Regimens

  • Takeshi Fujiwara
  • Kazuomi KarioEmail author
Chapter

Abstract

In this review, we introduce the main results of nine historical and landmark clinical trials, TOMHS, INSIGHT, LIFE, ALLHAT, ANBP2, CONVINCE, VALUE, ASCOT-CAFE, and ACCOMPLISH, that had a major impact on current guidelines for the management of hypertension. The most important objectives in the management of hypertension are to reduce BP levels significantly in the early phase and to reach the BP goals without fail, especially in high-risk patients with hypertensive complications. We must make every effort to confer the benefits of antihypertensive therapy to hypertensive patients, in order to reduce their cardiovascular outcomes and extend their healthy life spans.

Keywords

Blood pressure Lifestyles improvement Diuretic β-blocker ACE inhibitor CCB ARB Central aortic pressure 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Cardiovascular Medicine, Department of MedicineJichi Medical University School of MedicineShimotsukeJapan
  2. 2.Higashiagatsuma-machi National Health Insurance ClinicGunmaJapan
  3. 3.Division of Cardiovascular Medicine, Department of MedicineJichi Medical University School of MedicineTochigiJapan

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