Surgery Versus Nonsurgical Therapy for Recurrent Adrenocortical Carcinoma

  • Zahraa Al-Hilli
  • Melanie L. Lyden
Part of the Difficult Decisions in Surgery: An Evidence-Based Approach book series (DDSURGERY)


Adrenocortical carcinoma is a rare endocrine neoplasm associated with poor prognosis. Complete surgical resection is the only potential cure for the disease. Unfortunately, a significant number of patients develop disease relapse and present with local or systemic recurrence. Close follow-up with regular clinical examination aided by radiological imaging and blood investigations is crucial for the early detection of recurrent disease. The best treatment options for recurrent disease remain unclear and these include surgery, chemotherapy, and radiotherapy, in addition to new and upcoming treatments. This chapter will focus on the treatment of recurrent ACC including a discussion of surgical and non-surgical therapy options.


Adrenocortical carcinoma Recurrence Surgery Mitotane Chemotherapy Radiotherapy Radiofrequency ablation Treatment 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of General SurgeryCleveland ClinicClevelandUSA
  2. 2.Department of SurgeryMayo Clinic HospitalRochesterUSA

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