First-Line Therapy for Anaplastic Thyroid Cancer: Operation Versus Medical Management

  • Shabirhusain AbadinEmail author
  • Paritosh Suman
  • Jessica Hwang
  • Anu Thakrar
  • Subhash Patel
Part of the Difficult Decisions in Surgery: An Evidence-Based Approach book series (DDSURGERY)


Anaplastic thyroid cancer (ATC) is a highly lethal disease. First-line therapy for a patient diagnosed with this disease includes surgical resection or chemoradiation. Due to variable treatment and its rarity, there is a paucity of prospective and/or randomized controlled literature studying the initial therapy for patients diagnosed with ATC. To understand which therapy is more appropriate in terms of survival and quality of life, we evaluated the available literature and our own institutional experience with the management of ATC for recommendations regarding this topic. This chapter provides a summary of the pertaining literature and offers recommendations based on these sources for first-line management of a patient with newly diagnosed ATC.


Anaplastic thyroid cancer Carcinoma Thyroidectomy Surgery Chemoradiation Radiotherapy Chemotherapy 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Shabirhusain Abadin
    • 1
    Email author
  • Paritosh Suman
    • 2
  • Jessica Hwang
    • 3
  • Anu Thakrar
    • 4
  • Subhash Patel
    • 1
  1. 1.John H. Stroger, Jr. Hospital of Cook County, Department of SurgeryChicagoUSA
  2. 2.NorthShore University HealthSystem/John H. Stroger Hospital of Cook County, Department of SurgeryEvanstonUSA
  3. 3.John H. Stroger, Jr. Hospital of Cook County, Department of Endocrinology and DiabetesChicagoUSA
  4. 4.Department of Radiation OncologyJohn H. Stroger, Jr. Hospital of Cook CountyChicagoUSA

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